Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-07-26
1999-08-17
Grumbling, Matthew V.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436518, 549498, 549499, 544224, 548470, 548482, 548573, 546181, G01N 3353, G01N 33543
Patent
active
059392681
ABSTRACT:
This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries of diverse molecules which are easily differentially functionalized with various chemical moities and in one aspect are configured to act as non-hydrolyzable peptidomimetics.
REFERENCES:
patent: 4173646 (1979-11-01), Shepard et al.
patent: 4554106 (1985-11-01), DeLuca et al.
patent: 4863931 (1989-09-01), Schumacher et al.
patent: 5182366 (1993-01-01), Huebner et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5405830 (1995-04-01), Rendina et al.
Geysen, et al., Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid, Proc. Natl. Acad. Sci. USA, vol. 81, pp. 3998-4002, Jul. 1984.
Lam et al., A new type of synthetic peptide library for indentifying ligand-binding activity, Nature, vol. 354, Nov. 7, 1991, pp. 82-84.
Houghten et al., Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery, Nature, vol. 354, Nov. 7, 1991, pp. 84-86.
Journal of the American Chemical Society, vol. 116, No. 14, pp. 6101-6106, (Jul. 13, 1994) G. MacBeath et a., Monitoring Catalytis Activity by Immunoassay: Implications for Screening (See whole document).
Journal of the Chemical Society, Perkin Transactions No. 1, No. 11 pp. 1399-1406 (1992) Z. Xhou et al., Double Ring Closure of Diacetylenic Compounds With Activated Olefins in the Presence of a Cobalt (0) Catalyst, p. 1404, Figure 7A.
Grumbling Matthew V.
Northrup Thomas E.
The Scripps Research Institute
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