Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-02-04
1999-01-05
Green, Lora M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436518, 546 64, G01N 3353, C07D49100, C07D51300
Patent
active
058561072
ABSTRACT:
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
REFERENCES:
Gordon EM, et al, (1994) Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. J. Med. Chem. 37: 1385-1401, 1994.
Mayer et al., "Application Of the Pictet-Spengler Reaction In Combinatorial Chemistry." Tetrahedron Letters, 37(32):5633-5636 (1996).
Kaljuste and Unden, "Solid Phase Synthesis of 1,2,3,4-Tetrahydro-.beta.-carbolines; Implications for Combinatorial Chemistry." Tetrahedron Letters, 36(50):9211-9214 (1995).
Yang and Guo, "Pictet-Spengler Reaction On Solid Support." Tetrahedron Letters, 37(29):5041-5044 (1996).
Kanaoka et al., "Amino Acids and Peptides-II.sup.1. Cyclodehydration of Some Tryptophan-Dipeptides and Their Derivatives with Polyphosphate Ester." Tetrahedron, 24:2591-2594 (1968).
Ostresh et al., "Peptide Libraries: Determination of Relative Reaction Rates of Protected Amino Acids in Competitive Couplings." Biopolymers., 84:1661-1689 (1994).
Gordon et al., "Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions." J. of Med. Chem., 37(10):1386-1401 (1994).
Gallop et al., "Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries." J. of Med. Chem., 37(9):1233-1251 (1994).
Ostresh et al., "Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity." Proc. Natl., Acad. Sci. USA, 9:11138-11142 (1994).
Pinilla et al., "Rapid Identification of High Affinity Peptide Ligands Using Positional Scanning Synthetic Peptide Combinatorial Libraries." BioTecniques, 13(6):901-905 (1992).
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery." Nature, 354:84-86 (1991) .
Houghten Richard A.
Ostresh John M.
Green Lora M.
Trega Biosciences, Inc.
LandOfFree
Combinatorial libraries of imidazol-pyrido-indole and imidazol-p does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinatorial libraries of imidazol-pyrido-indole and imidazol-p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial libraries of imidazol-pyrido-indole and imidazol-p will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-861020