Combinatorial libraries of hydantoin and thiohydantoin derivativ

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530333, 530334, 530335, 525 541, 525 5411, 5483171, 5483195, C07K 104, C07K 400

Patent

active

058591907

ABSTRACT:
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.

REFERENCES:
patent: 5389614 (1995-02-01), Konis et al.
patent: 5612002 (1997-03-01), Cody et al.
Butain et al., J. Chem. Soc. Trans. I (1988) pp. 3175-3182.
Esser et al., Angew. Chem. vol. 90, No. 6 (1978) pp. 495-496.
DeWitt et al., "`Diversomers`": An approach to nonpeptide, nonoligomeric chemical diversity. Proc. Natl. Acad. Sci., 90:6909-6913 (1993).
DeWitt and Czarnik, "Combinatorial Organic Synthesis Using Parke-Davis's Diversomer Method." Acc. Chem. Res., 29(3) :114-122 (1996).
Hanessian and Yang, "Solution and Solid Phase Synthesis of 5-Alkoxyhydantoin Libraries with a Three-Fold Functional Diversity." Tetrahedron Letters, 37(33) :5835-5838 (1996).
Dressman et al., "Solid Phase Synthesis of Hydantoins Using a Carbamate Linker and a Novel Cyclization/Cleavage Step." Tetrahedron Letters, 37(7) :937-940 (1996).
Ostresh et al., "Peptide Libraries: Determination of Relative Reaction Rates of Protected Amino Acids in Competitive Couplings." Biopolymers., 84:1661-1689 (1994).
Gordon et al., "Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions." J. of Med. Chem., 37(10) :1386-1401 (1994).
Gallop et al., "Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries." J. of Med.Chem., 37(9) :1233-1251 (1994).
Ostresh et al., "Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity." Proc. Natl., Acad. Sci. USA, 9:11138-11142 (1994).
Pinilla et al., "Rapid Identification of High Affinity Peptide Ligands Using Positional Scanning Synthetic Peptide Combinatorial Libraries." BioTecniques, 13(6) :901-905 (1992).
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery." Nature, 354:84-86 (1991) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Combinatorial libraries of hydantoin and thiohydantoin derivativ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combinatorial libraries of hydantoin and thiohydantoin derivativ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial libraries of hydantoin and thiohydantoin derivativ will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1517470

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.