Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1996-11-07
1998-07-28
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530331, 530334, 5483164, 5483171, 544242, A61K 3812, C07D23338
Patent
active
057864489
ABSTRACT:
The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.
REFERENCES:
patent: 4795815 (1989-01-01), Ternansky
patent: 4940718 (1990-07-01), Barnett et al.
patent: 5182366 (1993-01-01), Huebner et al.
Singh et al., Indian J. Chem. vol. 14 B Jul. 1976 pp. 528-531.
Cuervo et al., "Polyalkylamine chemical combinatorial libraries." Peptides, 465-466 (1995).
Dorner et al., "The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations." Bioorg. & Med. Chem., 4(5) :709-715 (1996).
Gallop et al., "Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries." J. of Med. Chem., 37(9) :1233-1251 (1994).
Gordon et al., "Application of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions." J. of Med. Chem., 37 (10) :1386-1401 (1994).
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery," Nature, 354:84-86 (1991).
Kim et al., "Synthesis of a cyclic urea as a nonnatural biopolymer scaffold." Tetrahedron Lett., 37:5309-5312 (1996).
Lam et al., "Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors." Science, 263:380-384 (1994).
Ostresh et al., "Libraries from libraries: Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity." Proc. Natl. Acad. Sci., 91:11138-11142 (1994).
Ostresh et al., "Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries." Combinatorial Chemistry, 267:220-234 (1996).
Pinilla et al., "Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries." Biotechniques, 13:901-905 (1992).
Pinilla et al., "Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds." Drug Dev. Res., 33:133-145 (1994).
CA '86: 29756 N to Singh et al.
Houghten Richard
Nefzi Adel
Ostresh John M.
Celsa Bennett
Trega Biosciences, Inc.
Tsang Cecilia J.
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