Combinatorial kit for polymer synthesis

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Sample mechanical transport means in or for automated...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

422 99, 422100, 422101, 422102, 4352862, 4352864, 4352891, B01L 300

Patent

active

061362697

ABSTRACT:
A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

REFERENCES:
patent: 3281860 (1966-10-01), Adams et al.
patent: 3848998 (1974-11-01), Yonekura et al.
patent: 4031197 (1977-06-01), Marinkovich
patent: 4121222 (1978-10-01), Diebold et al.
patent: 4166457 (1979-09-01), Jacobsen et al.
patent: 4327073 (1982-04-01), Huang
patent: 4392362 (1983-07-01), Little
patent: 4483920 (1984-11-01), Gillespie et al.
patent: 4584277 (1986-04-01), Ullman et al.
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4607526 (1986-08-01), Bachenheimer et al.
patent: 4613566 (1986-09-01), Potter
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4677054 (1987-06-01), White et al.
patent: 4689405 (1987-08-01), Frank
patent: 4704256 (1987-11-01), Hood et al.
patent: 4704353 (1987-11-01), Humphries et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4728502 (1988-03-01), Hamill
patent: 4728591 (1988-03-01), Clark et al.
patent: 4746490 (1988-05-01), Saneii
patent: 4755458 (1988-07-01), Rabbani et al.
patent: 4820630 (1989-04-01), Taub
patent: 4828801 (1989-05-01), Lombardy wife Alric et al.
patent: 4833092 (1989-05-01), Geysen
patent: 4834946 (1989-05-01), Levin
patent: 4849513 (1989-07-01), Smith et al.
patent: 4855225 (1989-08-01), Fung et al.
patent: 4861420 (1989-08-01), Knutti et al.
patent: 4861866 (1989-08-01), Durrum et al.
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4874500 (1989-10-01), Madou et al.
patent: 4906439 (1990-03-01), Grenner
patent: 4923901 (1990-05-01), Koester et al.
patent: 4925785 (1990-05-01), Wang et al.
patent: 4943032 (1990-07-01), Zdeblick
patent: 4948565 (1990-08-01), Bemis et al.
patent: 4966646 (1990-10-01), Zdeblick
patent: 4978507 (1990-12-01), Levin
patent: 4981783 (1991-01-01), Augenlicht et al.
patent: 4987065 (1991-01-01), Stavianopoulos et al.
patent: 4988617 (1991-01-01), Landegren et al.
patent: 4994373 (1991-02-01), Stavrianopoulos et al.
patent: 4996646 (1991-02-01), Zdeblick
patent: 4997521 (1991-03-01), Howe et al.
patent: 5002867 (1991-03-01), Macevicz
patent: 5026773 (1991-06-01), Steel
patent: 5026840 (1991-06-01), Dattagupta et al.
patent: 5028525 (1991-07-01), Gray et al.
patent: 5037882 (1991-08-01), Steel
patent: 5043265 (1991-08-01), Tanke et al.
patent: 5053454 (1991-10-01), Judd
patent: 5082830 (1992-01-01), Brakel et al.
patent: 5100626 (1992-03-01), Levin
patent: 5110555 (1992-05-01), Moore et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5175209 (1992-12-01), Beattie et al.
patent: 5200051 (1993-04-01), Cozzette
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5215882 (1993-06-01), Bahl et al.
patent: 5232829 (1993-08-01), Longiaru et al.
patent: 5250263 (1993-10-01), Manz
patent: 5279558 (1994-01-01), Kriesel
patent: 5310523 (1994-05-01), Smithers et al.
patent: 5310893 (1994-05-01), Erlich et al.
patent: 5348855 (1994-09-01), Dattagupta et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5429807 (1995-07-01), Matson et al.
patent: 5436327 (1995-07-01), Southern et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5447841 (1995-09-01), Gray et al.
patent: 5700637 (1997-12-01), Southern
Abbott et al., "Manipulation of the Wettability of Surfaces of the 0.1- to 1-Micrometer Scale Through Micromachining and Molecular Self-Assembly," Science 257:1380-1382 (1992).
Bhatia et al., "New Approach to Producing Patterned Biomolecular Assemblies," J. Am. Chem. Soc., 114:4432-4433 (1992).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis," Science 251:767-777 ().
Frank et al., Nucleic Acids Research, 11:4365-4377 (1983).
Frank et al., "Simultaneous Multiple Peptide Synthesis Under Continuous Flow Conditions on Cellulose Paper Discs as Segmental Solid Supports," Tetrahedron, 44:(19)6031-6040 (1988).
Haridasan et al., "Peptide Synthesis Using Photolytically Cleavable 2-Nitrobenzyloxycarbonyl Protecting Group," Proc. Indian Natl. Sci. Acad., 53:717-728 (1987).
Knutti, "Energying Silicon Microstructures," Undated.
Knutti, "Advanced Silicon Microstructures," presented at ASICT Conference; Apr. 11, 1989; Toyohashi, Japan.
Knutti, "Silicon Microsystems as an Industry," presented at Microsystems 1990; Sep. 10-13, 1990; Berlin, Germany.
Southern et al., "Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation Using Experimental Models," Genomics, 13:1008-1017 (1992).
Sze, "Lithography," VLSI Technology, Chapter 7, McGraw-Hill Book Company, Chapter 7, pp. 267-301 (1983).
Tonucci et al., "Nanochannel Array Glass," Science, 258:783-785 (1992).
Geysen, et al., (1987), Strategies For Epitope Analysis Using Peptide Synthesis, Journal of Immunological Methods, 102:259-274.
Ghandi, (1983), Lithographic Processes, In VLSI Fabrication Principles; Silicon and Gallium Arsenide, Ch.10;535-565, John Wiley & Sons, New York.
Merrifield, (1963), Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide, J. Am. Chem. Soc., 85:2149-2154.
Stryer, (1995), Biochemistry, Chapter 2, pp. 20-23, W.H. Freeman &Co.
Urdea et al., "A Novel Method for the Rapid Detection of Specific Nucleotide Sequences in Crude Biological Samples Without Blotting or Radioactivity; Application to the Analysis of Hepatitis B Virus in Human Serum," Gene 61, 253-264 (1987).
Frank, et al., "Simultaneous Synthesis and Biological Applications of DNA Fragments: An Efficient and Complete Methodology," Methods in Enzymology, 154:221-251 (1987).
Augenlicht, et al., "Cloning of Screening of Sequences Expressed in a Mouse Colon Tumor," Cancer Research, 42, 1088-1093.
Masiakowski, et al., "Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line," Nucleic Acids Research, 10:7895-7903 (1982).
Bartsh et al., "Cloning of mRNA sequences from the human colon: Preliminary characterization of defined mRNAs in normal neoplastic tissues," Br. J. Cancer, 54:791-798 (1986).
Haase et al "Detection of two Viral Genomes in Single Cells by Double-Label Hybridization in Situ and Color Microradioautography," Science 227, 189-192 )1985).
Lanier, et al, "Human Lymphocyte Subpopulations Identified by Using Three-Color Immunofluorescence and Flow Cytometry Analysis", The Journal of Immunology, 132:151-156 (1984).
Wallace et al.,"Hybridization of synthetic oligodeoxyribonucleotides to *x 174 DNA: the effect of single base pair mismatch"Nucleic Acids Research, 11:3543-3557 (1979).
Laskey, et al., "Messenger RNA prevalence in sea urchin embryos measured with cloned cDNAS," Proc. Natl. Acad. Sci. USA, 77:5317-5321 (1986).
Hanahan et al., "Plasmid screening at high colony density", Gene 10:63-67 (1980).
Hanahan et al., "Plasmid screening at high density," Methods in Enzymology, 100:333-342 (1983).
Love, et al., "Screening of Lambda Library for Differentially Expressed Genes Using in Vitro Transcripts," Anal Biochem, 150:429-41 (1985).
Wu, et al., "Synthesis and Properties of Adnosine-5'-triphosphoro-y-1-(5-sulfonic acid) naphthyl Ethylamidate: A Flurorescent Nucleotide Substrate for DNA-Dependent RNA Polymerase from Escherichia coli" Arch Biochem Biophys, 246:564-71 (1989).
Yarbrough, et al., "Synthesis and Properties of Flourescent Nucleotide Substrates for DNA-depedent RNA Polymerases," J. Biol. Chem. 254:12069-73 (1979).
Titus, et al., "Texas Red, A Hydrophilic, Red-Emitting Fluorophore for use with Fluorescein in Dual Parameter Flow Microfluorometric and Fluorescence Microscopic Studies," Journal of Immunological Methods, 50:193-204. (1982).
*Loken, et al, "Three-Color Immunofluorescence Analysis of Leu Antigens on Human Peripheral Blood Using Two Lasers on a Fluorescence-Activated Cell Sorter," Cymoetry 5:151-158 (1984).
Sim, et al., "Us

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Combinatorial kit for polymer synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combinatorial kit for polymer synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial kit for polymer synthesis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1960428

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.