Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1996-11-05
1999-10-26
Adams, Donald E.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436523, 436524, 435 71, 564193, G01N 3353, G01N 33543, G01N 33551, C07C 2300
Patent
active
059727195
ABSTRACT:
Combinatorial chemical libraries of Formula I ##STR1## and methods for their preparation are disclosed. The libraries allow one to screen large numbers of compounds for a desired biological activity with relative ease. The libraries may be tagged or untagged. In preferred libraries, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. The use of the libraries to discover biologically active compounds is also disclosed.
REFERENCES:
patent: 4755592 (1988-07-01), Raddatz et al.
patent: 5618825 (1997-04-01), Baldwin et al.
Gordon EM, et al, (1994) Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. J Med. Chem. 37:1385-4101, 1994.
Dolle, III Roland Ellwood
Guo Tao
He Zhen Min
Johnson, Jr. Theodore Otto
Patel Hitesh K.
Adams Donald E.
Pharmacopeia Inc.
Ricigliano Joseph W.
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