Combinatorial fluorescent library based on the styryl scaffold

Details Combinatorial fluorescent library based on the styryl scaffold Combinatorial fluorescent library based on the styryl scaffold

2004-07-01

2008-03-04

Schultz, J. Douglas (Department: 1639)

Combinatorial chemistry technology: method, library, apparatus

Library, per se

Library containing only organic compounds

Reexamination Certificate

active

07338428

ABSTRACT:
A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.

REFERENCES:
Khersonsky, Sonya M., et al., Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening, J. Am. Chem. Soc. 2003, Sep. 9, 2003, pp. 11804-11805, vol. 125, No. 39, New York.
Lee, Jae Wook, et al., Development of Novel Cell-Permeable DNA Sensitive Dyes Using Combinatorial Synthesis and Cell-Based Screening, The Royal Society of Chemistry 2003, Jun. 23, 2003, pp. 1852-1853.
Rosania, Gustavo R., et al., Combinational Approach to Organelle-Targeted Fluorescent Library Based on the Styryl Scaffold, J. Am. Chem. Soc. 2003, Jan. 14, 2003, pp. 1130-1131, vol. 125, No. 5, New York.
Uttamchandani, Mahesh, et al., Microarrays of Tagged Combinational Triazine Libraries in the Discovery of Small-Molecule Ligands of Human IgG, Journal of Combinational Chemistry 2004.
Williams, Darren, et al., Identification of Compounds That Bind Mitochondrial F1F0 ATPase by Screening a Triazine Library for Correction of Albinism, Chemistry & Biology, Sep. 2004, pp. 1251-1259, vol. 11.

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