Combinatorial biaryl amino acid amide libraries

Details Combinatorial biaryl amino acid amide libraries Combinatorial biaryl amino acid amide libraries

1997-06-16

1999-09-07

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436524, 436527, 436530, 436501, 530333, 530334, G01N 33543, G01N 33551, G01N 33544, A61K 3800

Patent

active

059486961

ABSTRACT:
and -L'-Z is a linker/compound residue. In these libraries, Z is --NR.sup.1 R.sup.2. R.sup.1 is chosen from H, C.sub.1 to C.sub.20 hydrocarbon, heteroaralkyl, heterocycloalkyl, substituted arylalkyl, alkoxyalkyl or alkyl-SO.sub.2 NH-alkyl and R.sup.4 is an acyl or sulfonyl residue. R.sup.2 is chosen from ##STR1## The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.

REFERENCES:
patent: 5481020 (1996-01-01), Ng et al.
patent: 5734054 (1998-03-01), Dolle, III et al.
patent: 5766963 (1998-06-01), Baldwin et al.
Zuckermann et al. "Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled . . . " J. Med. Chem. 37, 2678-2685 (1994).
Shieh et al. "A Simple Asymmetric Synthesis of 4-Arylphenylalanines via Palladium-Catalyzed . . . " J. Org. Chem. 57, 379-381 (1992).
Burk et al. "Versatile Tandem Catalysis Procedure for the Preparation of Novel . . . " J. Am. Chem. Soc. 116, 10847-10848 (1994).
Ksander et al. "Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors" J. Med. Chem. 38, 1689-1700 (1995).
Guiles et al. "Solid-Phase Suzuki Coupling for C-C Bond Formation" J. Org. Chem. 61, 5169-5171 (1996).
Frenette et al. "Biaryl Synthesis via Suzuki Coupling on a Solid Support" Tetrahedron Letters 35, 9177-9180 (1994).
Han et al. "Silicon Directed ipso-Substitution of Polymer Bound Arylsilanes: . . . " Tetrahedron Letters 37, 2703-2706 (1996).
Martin et al. "Palladium-Catalyzed Cross-Coupling Reactions of Organoboronic . . . " Acta Chemica Scandinavica 47, 221-230 (1993).

Affiliated with

Also associated with

Rating

Combinatorial biaryl amino acid amide libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combinatorial biaryl amino acid amide libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinatorial biaryl amino acid amide libraries will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1804105