Combinatorial amide alcohol libraries

Details Combinatorial amide alcohol libraries Combinatorial amide alcohol libraries

1997-04-14

1999-11-02

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436518, 435 71, 564201, G01N 33566, G01N 33543, G01N 3353

Patent

active

059768940

ABSTRACT:
Combinatorial chemical libraries of the Formula [S]-C(O)-L'-Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and -L'-Z is a linker/ligand residue. In these libraries, Z is ##STR1## and Y is --P(O)(OR.sup.6)(OR.sup.7), --CH(OH)--COR.sup.8, --CH.sub.2 CH.dbd.CH.sub.2 --CH.sub.2 CH(OH)CH.sub.2 OH, --CH.sub.2 CHO, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OC(O)NHR.sup.26, --CH.sub.2 CH.sub.2 NR.sup.27 R.sup.28, or ##STR2## The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.

REFERENCES:
patent: 5565324 (1996-10-01), Still et al.
patent: 5712171 (1998-01-01), Zambias et al.
Rotella "Solid Phase Synthesis of Olefin and Hydroxyethylene Peptidomimetics" J. Am. Chem. Soc. 118, 12246-12247 (1996).
Murphy et al. "Combinatorial Organic Synthesis of Highly Functionalized . . . " J. Am. Chem. Soc. 117, 7029-7030 (1995).
Baldwin et al. "Synthesis of a Small Molecule Combinatorial Library Encoded . . . " J. Am. Chem. Soc. 117, 5588-5589 (1995).
Wang et al. "Synthetic Chemical Diversity: Solid Phase Synthesis of Libraries . . . " J. Med. Chem. 38, 2995-3002 (1995).
Kick et al. "Expedient Method for the Solid-Phase Synthesis of Aspartic Acid . . . " J. Med. Chem. 38, 1427-1430 (1995).
Gordon et al. "Applications of Combinatorial Technologies to Drug Discovery . . . " J. Med. Chem. 37, 1385-1401 (1994).

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