Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2005-06-21
2005-06-21
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C514S453000, C514S468000
Reexamination Certificate
active
06908630
ABSTRACT:
A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component of a sesquiterpene lactone species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
REFERENCES:
patent: 5500340 (1996-03-01), Lipsky et al.
patent: 5962516 (1999-10-01), Qi et al.
patent: 6271213 (2001-08-01), Henderson et al.
patent: 6333304 (2001-12-01), Bath et al.
patent: 6346519 (2002-02-01), Petrus
patent: 4212122 (1993-10-01), None
patent: 07033668 (1995-02-01), None
Tao et al. Arthritis & Rheumatism (Jan. 1998), vol. 41(1): 130-138. Effects of Tripterygium wilfordii Hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production.
Hwang et al. Biochemical & Biophysical Research Communications (1996), vol. 226(3): 810-818. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of.
H. Sumner, U. Salan, D. W. Knight and J.R.S. Hoult—Inhibition of 5-Lipoxygenase and Cyclo-Osygenase in Leukocytes by Feverfew (Involvement of Sesquiterpene Lactones and Other Components).Biochem. Pharmacol. 1992: 43(11):2313-20.
W. A. Groenwegen, D. W. Knight, S. Heptinstall—Compounds Extracted from feverfew that have Anti-secretory Activity contain an α-methylene Butyrolactone Unit—J. Pharm Pharmacol. 1986 38(9):709-12.
V. J. Pugh, K. Sambo,J. Pharm. Pharmacol. 1988 40(10):743-5—Prostaglandin Synthetase Inhibitors in Feverfew.
Tournier, et al. Effect of the Chloroform Extract of Tanacetum vulg. Feb. 1999;51(2):215-9 vol. 51J. Pharm. Pharmacol.
Hehner, et al. The Antiinflammatory Sequiterpene Lactone Parthen Nov. 15, 1999; 163(10):5617-23 vol. 163J. Immunol.
H. R. Wong and I. Y. Menendez—Seswquiterpene Lactones Inhibit Inductible Nitric Oxide Synthase Gene Expression in Cultured Rat Aortic Smooth Muscle Cells—Biochem. Biophys. Res. Commun. 1999 27:262(2):375-80.
Lopes Vaz, A., Double-blind Clinical Evaluation of the Relative Efficacy of Ibuprofen and Glucosamine Sulphate in the Management of Osteoarthritis of the Knee in Outpatients, 8Curr. Med Res Opin. 145-149 (1982).
P. K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, etc.—Measurement of Protein Using Bicinchoninic Acid.Anal. Biochem. 1985 (150(1):76-85.
Noreen, Y., et al. (J. Nat. Prod. 61, 2-7, 1998) Development of a Radiochemical Cyclooxygenase-1 and -2 in Vitro Assay for Indentification of Natural Products as Inhibitors of Prostaglandin Biosynthesis (The ability of a Test Material to Inhibit COX-1 Synthesis of PGE2.).
Hamberg, M. and Samuelsson, B. (J. Biol. Chem. 1971, 246,6713-6721) On the Metabolism of Prostaglandins E1 and E2 in Man (Determination of PGE2 Concentration in Medium).
T. C. Chou and P. Talaly—Median Effect Methods Described (Trends Pharmacol. Sci. 4:450-454).
T-C Chou and P. Talalay—A Simple Generalized Equation for the Analysis of Multiple Inhibitions of Michaelis-Menten Kinetic Systems—Journal of Biological Chemistry, vol. 252. No. 18, 6438-6442, 1977.
P. M. Bork, M. Lienhard Schmitz, M. Kuhnt, etc.—Sesquiterpene Lactone Containing Mexican Indian Medicinal Plants and Pure Sesquiterpene Lactones as Potent Inhibitors of Transcription Factor NF—B—FEBS Letters1997 27: 402(1):85-90.
X Tao, J J Cai and P E Lipsky—The identity of Immunosuppressive Components of the Ethyl Acetate Extract and Chloroform Methanol Extract (T2) of Tripterygium Wilfordii Hook.F Journal of Pharmacology and Experimental Therapeutics1995 272:1305-1312.
H Towbin, T Staehelin and J Gordon—Electrophoretic Transfer of Proteins from Polyacrylamide gets to Nitrocellulose Sheets; Procedure and some Applications—Proc. Natl. Acad. Sci. USAvol. 76, No. 9, pp 4350-4554, 1979.
U K Laemmli and M Favre—Maturation of the Head of Bacteriophage T4 1. DNA Packaging Events—J. Mol. Biol. (1973) 80, 575-599.
Babish John G.
Howell Terrence
Pacioretty Linda
Flood Michele C.
McDermott & Will & Emery
Metaproteomics, LLC
Tate Christopher R.
LandOfFree
Combinations of sesquiterpene lactones and ditepene... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinations of sesquiterpene lactones and ditepene..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations of sesquiterpene lactones and ditepene... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3478253