Combinations of renal vasodilators and .alpha..sub.1 -adrenergic

Details Combinations of renal vasodilators and .alpha..sub.1 -adrenergic Combinations of renal vasodilators and .alpha..sub.1 -adrenergic

1986-12-04

1988-06-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702

Patent

active

047496860

ABSTRACT:
This invention relates to combinations and methods for the treatment of renal disease, cardiovascular disease and hypertension. More particularly, the invention relates to combinations of renal vasodilators and .alpha..sub.1 -adrenergic or ganglionic blocking agents. According to a preferred embodiment, atriopeptins having renal vasodilator activity are used in combination with .alpha..sub.1 -adrenergic blocking agents for treating renal disease, cardiovascular disease and hypertension. The blocking agent promotes sustained renal vasodilation, thereby enhancing renal blood flow and kidney function.

REFERENCES:
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Chem. Abstr. vol. 103 (1985) 64636.
Chem. Abstr. vol. 106 (1987) 60959.
Chem. Abstr. vol. 105 (1986) 209252.
Chem. Abstr. vol. 104, (1986) 82397.
Chem. Abstr. vol. 103 (1985) 87727.
Chem. Abstr. vol. 99, (1983) 191046.

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