Combinations of reboxetine and neuroleptic agents

Details Combinations of reboxetine and neuroleptic agents Combinations of reboxetine and neuroleptic agents

2005-11-15

2005-11-15

Spivack, Phyllis G. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S220000, C514S259410

Reexamination Certificate

active

06964962

ABSTRACT:
A composition comprising:(a) a pharmaceutically effective amount of reboxetine; and selected from the group consisting of clozapine, olanzapine, risperidone and mixtures thereof(b) a pharmaceutically effective amount of one or more neuroleptic agents or a pharmaceutically effective salt thereof is provided.

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Koch et al, Eur. J. Clin. Pharmacol. (56, No. 6-7, A10, 2000) (abstract).
E. Aragues, et al., “Reboxetine in Negative Symptoms of Schizophrenia”, European Psychiatry, 2000, pp 426S, Abstract Only.
G. Schutz, et al., “Reboxetine Add on Therapy to Haloperidol in The Treatment of Schizophrenia: a Preliminary Double-blind Randomized Placebo-controlled Study”, International Clinical Psychopharmacology, 2001, pp 275-278, vol. 16, No. 5.
E. Spina, et al, “No Effect of Reboxetine on Plasma Concentrations of Clozapine, Risperidone, and Their Active Metabolites”, 2001, pp675-678, vol. 23 No. 6.

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