Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1996-02-20
1998-10-13
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435193, 435194, 435 71, 435 723, 424 92, C12Q 148, C12N 910
Patent
active
058210725
ABSTRACT:
This invention provides methods for screening protein kinase C inhibitors capable of potentiating apoptosis in tumor cells. This invention also provides methods for screening antitumor therapeutic agents suitable for combination therapy with a protein kinase C inhibitors capable of potentiating apoptosis in tumor cells. This invention further provides different combination therapies comprising the specific protein kinase C inhibitors and the antitumor therapeutic agents.
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Schwartz, et al., (1991) "Protein Kinase C Activity and Multidrug Resistance in MOLT-3 Human Lymphoblastic Leukemia Cells Resistant to Timetrexate", Cancer Research, vol. 51: 55-61.
Schwartz, et al., (1995) "Potentiation of Apoptosis by Treatment with Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells", Journal of the National Cancer Institute, vol. 87: 1394-1399.
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Lane (1993), Nature 362: 786-787. "A death in the life of p. 53".
Albino Anthony P.
Schwartz Gary K.
Nashed Nashaat T.
Sloan-Kettering Institute for Cancer Research
Wax Robert A.
White John P.
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