Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1998-07-24
1999-12-14
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424450, 424 7837, 514 63, 514552, 514880, A61K 706
Patent
active
060013788
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to novel combinations of peroxidised lipids and organosilicon compounds, cosmetic and dermatological compositions containing them, as well as to their applications, especially for the treatment of alopecia.
Hair loss, also known as alopecia, is a problem which is most particularly spread over the whole of the population, especially in the male population but also in the female population.
Many studies have been dedicated to this problem. As regards female alopeciae disseminatae, the development on female alopeciae disseminatae, carried out by P. Reygagne, and which appear in bedc, 1993, 1, 7, 327-338, may be cited in particular. In this study, it emerges that alopeciae disseminatae are currently the subject of three types of treatment: vitamin B8, cases, but the positive effect of which ceases to manifest itself in the 3 to 6 months following the stopping of the applications,
In general, androgenetic alopecia is the most frequent of alopeciae and, without doubt, that for which the therapeutic demand is the highest. However, the anti-androgenetic treatments per os which have a certain effectiveness in the woman are not practical in the man and no local anti-androgenetic treatment has found long-lasting effectiveness. The only local treatment being able to demonstrate in several controlled studies a certain effectiveness in the man is minoxidil in a twice-weekly local application. The first studies made between 1982 and 1986 were relatively optimistic with 18 to 53% re-growth. Such a study is given in: Androgenic alopecia: clinical aspects and treatment, in "Hair and Hair Diseases" C. E. ORPHANOS, R HAPPLE (Eds), Springer-Verlag, Berlin Heidelberg 1990, PP 485-527. Cosmetically acceptable re-growths are in fact rare, as related by RUSHTON D. H., VUGER W. P., COTTERIL P. C., KINGSLEY P., JAMES K. C. in "Quantitative assessment of 2% topical Minoxidil in the treatment of male pattern baldness", Clin Exp Dermatol, 1989, 14, 40-6. Moreover, OLSEN E. A., WEINER M. S. AMARA I. A., DELONG E. R., have indicated in the article entitled "Five-year follow-up of men with androgenetic alopecia treated with topical Minoxidil" in J. Am Acad Dermatol 1990, 22, 643-6, a slow return of the hair loss after 1 year of treatment, even if the treatment is continued. Furthermore, a systemic diffusion limits the increase in the local concentration of minoxidil and the preparations currently marketed are all dosed at 2% minoxidil.
Various peroxidised lipids are known, which are notably obtained by a peroxidation of natural vegetable oil. The following patents shall be cited in particular: BSM N.degree.2 330 M, EP-A-293 535, FR-A-2 591 112, EP-A-225 831, EP-A-225 832, EP-A-225 833, EP-A-226 506, FR-A-2 461 744, FR-A-2 539 142 and EP-A-117 962, which relate either to the preparation of such peroxidised lipids, or to their applications in various fields, particularly in the treatment of certain illnesses in the field of rheumatology or traumatology, or even as a healing product.
Peroxidised lipids of this type have also been used according to European patent EP-A-0 480 983 for the treatment of circulatory insufficiencies by local application.
Many references are found in the literature which relate to the activity of organic silicon on the stimulation of the biosynthesis of collagen or of elastin, in the reconstitution of the damaged connective tissue. It emerges from the experimental works given in the various publications, that in particular, the organic silicon causes a return to a normal level of the arterial wall degraded by the attack of an artificially caused atheroma.
More specifically, in J. Med. Esth and Chir. Derm., volume XII, 47, September 1985, pages 187-190, F. MARCHI-LIPSKI and F. DANIEL have carried out a bibliographical analysis concerning the therapeutic interest of silicon in the ageing of connective tissue. It emerges from this study that silicon has a most particular importance in the upkeep of the integrity of connective tissue and that the organosilicon derivatives enable efficiently
REFERENCES:
patent: 5254585 (1993-10-01), Desjonqueres
Dees Jos,e G.
Laboratoires Carilene
Williamson Michael A.
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