Combinations of penicillanic acid 1,1-dioxide with 7-(D-2-[4-eth

Details Combinations of penicillanic acid 1,1-dioxide with 7-(D-2-[4-eth Combinations of penicillanic acid 1,1-dioxide with 7-(D-2-[4-eth

1979-03-05

1981-06-30

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

H61K 3500

Patent

active

042762855

ABSTRACT:
Penicillanic acid 1,1-dioxide, pharmaceutically-acceptable salts thereof, and esters thereof readily hydrolyzable in vivo, enhance the antibacterial effectiveness of 7-(D-2-[4-ethylpiperazin-2,3-dione-1-carboxamido]-2-[4-hydroxyphenyl]aceta mido)-3-([1-methyl-5-tetrazolyl]thiomethyl)-3-desacetoxymethylcephalosporan ic acid, and salts thereof, against many beta-lactamase producing bacteria.

REFERENCES:
patent: 3197466 (1965-07-01), Chow et al.
patent: 3536698 (1970-10-01), Chauvette et al.
Guddal et al., Tetrahedron Letters, No. 9, 381, (1962).
Harrison et al., J. Chem. Soc., (London), Perkin I, 1977, (1976).
Antibiotiki, 73, pp. 155-158, (1967).
Chemical Abstracts 88:22943d, (1978), Abstracting S. African Pat. No. 7600296 Published 11-16-76.
Busson et al., "Recent Advances in the Chemistry of B-Lactan Antibiotics," J. Elka, Ed., Burlington House, London, 1977, Chapter 32, pp. 304-313.

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