Combinations of FU and BVU as anti-adenocarcinoma agents

Details Combinations of FU and BVU as anti-adenocarcinoma agents Combinations of FU and BVU as anti-adenocarcinoma agents

1989-06-29

1991-01-29

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514274, A61K 3170, A61K 31505

Patent

active

049886789

ABSTRACT:
The antitumor activity of 5-fluorouracil and its precursors against adenocarcinomas can be potentiated without a corresponding increase in toxicity by combining these compounds with (E)-5-(2-bromovinyl)-uracil or a precursor thereof. The combinations may have the form of a single composition or two separate compositions.

REFERENCES:
patent: 4650801 (1987-03-01), Fujii et al.
Chester et al., Chemotherapy of Cot, 2nd Ed., John Wiley & Sons, N.Y., N.Y., (1981), pp. 77-78.
Effect of (E)-5-(2 Bromovinyl) Uracil on the Catabolism and Antitumor Activity of 5-Fluorouracil in Rats and Leukemic Mice, Can. Res. 46, 1094-1101, 1986.
Potential of Bromovinyl Deoxyuridine in Anticancer Chemotherapy Clercq., Anticancer Res. 6, 549-556 (1986).
C. Desgranges et al., Nucleric Acid Research, 12, 2081-2090 (1984).
C. Desgranges et al., Cancer Research, 46, 1094-1101 (1986).
E. De Clercq, Anticancer Research, 6, 549-556 (1986).
E. De Clercq, Verhandelingen Kon. Acad. Geneeskunde Belgie, 48, 261-290 (1986).
Iigo et al., Japan Journal of Cancer Research (Gann), 78, 409-413, (1987).
Iigo et al., Eur. Journ. Cancer Clin. Oncol., 23, 773-777 (1987).
Iigo et al., Biochem. Pharmacol., 37, 1609-1613, (1988).

Affiliated with

Also associated with

Rating

Combinations of FU and BVU as anti-adenocarcinoma agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Combinations of FU and BVU as anti-adenocarcinoma agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations of FU and BVU as anti-adenocarcinoma agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-813804