Combinations of dipeptidyl peptidase IV inhibitors and other...

Details Combinations of dipeptidyl peptidase IV inhibitors and other... Combinations of dipeptidyl peptidase IV inhibitors and other...

2007-07-10

2007-07-10

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S275000, C514S255060, C514S003100, C514S342000, C514S343000, C514S369000, C514S423000, C514S470000, C514S492000, C514S563000, C514S592000

Reexamination Certificate

active

11421548

ABSTRACT:
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of a dipeptidyl peptidase IV inhibitor and another antidiabetic agent, to a mammal in need thereof.

REFERENCES:
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patent: 2003/0139434 (2003-07-01), Balkan et al.
patent: 0 306 228 (1989-03-01), None
patent: WO-98/19998 (1998-05-01), None
patent: WO-99/61431 (1999-12-01), None
patent: WO-01/52825 (2001-07-01), None
Deacon et al.; “Dipeptidyl Peptidase IV Inhibition Potentiates the Insulinotropic Effect of Glucogen-like Peptide 1 in the Anethesized Pig”; Diabetes; 1998; 47/5; pp. 764-769.
Hoffamn et al.; Diabetes Care; 1992; 15/8; pp. 1075-1078.
Holst et al; “Inhibition of the Activity of Dipeptidyl-Peptidase IV as a Treatment for Type 2 Diabetes”; Diabetes; 1998; 47; pp. 1663-1670.
Hotta; Chronic Disease; 1995; 6/1; pp. 97-102.
Hotta; Tonyobo Update; 1994; 10; pp. 68-77.
Lebovitz; Diabetes Care; 1994; 17/12; pp. 1542-1544.
Pauly et al.; “Improved Glucose Tolerance in Rats Treated with the Dipeptidyl Peptidase IV (CD26) Inhibitor I1e-Thiazolidide”; Metabolism, Clinical and Experimental; 1999; 48/3; pp. 385-389.
Williams; Lancet; 1994; 343; pp. 95-100.

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