Combinations of dipeptidyl peptidase IV inhibitors and other...

Details Combinations of dipeptidyl peptidase IV inhibitors and other... Combinations of dipeptidyl peptidase IV inhibitors and other...

2006-07-18

2006-07-18

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07078397

ABSTRACT:
Disclosed is a method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of a dipeptidyl peptidase IV inhibitor and another antidiabetic agent, to a mammal in need thereof.

REFERENCES:
patent: 6274608 (2001-08-01), Sauerberg et al.
patent: 0 306 228 (1989-03-01), None
patent: WO 98/19998 (1998-05-01), None
patent: WO 99/61431 (1999-12-01), None
patent: WO 01/52825 (2001-07-01), None
Pauly et al., “Improved Glucose Tolerance in Rats Treated with the Dipeptidyl Peptidase IV (CD26) Inhibitor Ile-Thiazolidide”,Metabolism, Clinical and Experimental,48(3): 385-389 (1999).
Deacon et al., “Dipeptidyl Peptidase IV Inhibition Potentiates the Insulinotropic Effect of Glucogon-like Peptide 1 in the Anesthetized Pig”,Diabetes,47(5): 764-769 (1998).
Holst et al., “Inhibition of the Activity of Dipeptidyl-Piptidase IV as a Treatment for Type 2 Diabetes”, 47: 1663-1670 (1998).

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