Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Reexamination Certificate
2011-03-15
2011-03-15
Goddard, Laura B (Department: 1642)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
C424S158100, C424S178100, C424S183100
Reexamination Certificate
active
07906115
ABSTRACT:
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 4287188 (1981-09-01), Schaeffer
patent: 4665062 (1987-05-01), Eriksson et al.
patent: 4771041 (1988-09-01), Eriksson et al.
patent: 5512596 (1996-04-01), Kim et al.
patent: 6300308 (2001-10-01), Schroit
patent: 6312694 (2001-11-01), Thorpe et al.
patent: 6406693 (2002-06-01), Thorpe et al.
patent: 6486166 (2002-11-01), Albrecht et al.
patent: 6783760 (2004-08-01), Thorpe et al.
patent: 6806354 (2004-10-01), Schroit
patent: 6818213 (2004-11-01), Thorpe et al.
patent: 7067109 (2006-06-01), Thorpe et al.
patent: 7422738 (2008-09-01), Thorpe et al.
patent: 7455833 (2008-11-01), Thorpe et al.
patent: 7790159 (2010-09-01), Thorpe et al.
patent: 2002/0025319 (2002-02-01), Brams
patent: 2003/0004097 (2003-01-01), Schroit
patent: WO 00/02584 (2000-01-01), None
patent: WO 00/02587 (2000-01-01), None
patent: WO 01/03735 (2001-01-01), None
patent: WO 01/66785 (2001-09-01), None
patent: WO 01/68709 (2001-09-01), None
Ran et al (Clinical Cancer Research, 2005, 11:1551-1562).
Luster et al (J of Biological Chemistry, 2006).
Janeway et al (Immunobiology, 2001, 5th Ed., Garland Publishing, New York).
Horkko et al (J Clin Investigation, 1996, 98:815-825).
Loffler et al (Current Microbiology, 1983, 8:187-190).
Kennedy (Cancer Research, sppl; 1994, 54:1999s-2005s).
Pati et al (Blood, May 2002, 99:3771-3779).
Bevers et al (Clinical Immunology, 2004, 112:150-160).
Luster et al (J Biological Chemistry, 2006, 281:29863-71, IDS).
Ran et al (Clinical Cancer Research, 2005, 11:1551-1562, IDS).
Rote et al (Clinical Immunology and Immunopathology, 1993, 66:193-200, IDS).
US Court of Appeals for the Federal Circuit, In re Alonso, Oct. 2008 (p. 1-11 + cover).
Aggarwal and Ranjan, “Preventing and Treating Hepatitis B Infection”,BMJ, 329:1079-1086, 2004.
Borda et al., “Cell Tropism of Simian Immunodeficiency Virus in Culture Is Not Predictive of In Vivo Tropism or Pathogenesis”,Am. J. Pathol., 165(6):2111-2122, 2004.
De Palma, “Looking Inside the Black Box/Biological Pathways and Drug Discovery”,New York Academy of Sciences, 1-3, 2006.
Ford et al., “The Intracellular Pharmacology of Antiretroviral Protease Inhibitors”,J. Antimicrobial Chemotherapy, 54:982-990, 2004.
Gait and Karn, “Progress in Anti-HIV Structure-Based Drug Design”,TIBTech, 13:430-438, 1995.
Janeway et al., “The Interaction of the Antibody Molecule with Specific Antigen”,Immunobiol., 5th ed., 7 pages, 2001.
Locarnini and Shaw, “Antiviral Drug Resistance in Hepatitis B and C”,J. Gastroenterol. Hepatol., 19:S322-S328, 2004.
Peter and Gambertoglio, “Intracellular Phosphorylation of Zidovudine (ZDV) and Other Nucleoside Reverse Transcriptase Inhibitors (RTI) Used for Human Immunodeficiency Virus (HIV) Infection”,Pharmaceutical Res., 15(6):819-825, 1998.
Rodriguez et al., “Intracellular Studies of the Nucleoside Reverse Transcriptase Inhibitor Active Metabolites: a Review”,Biochemistry, 19(1):19-27, 2000.
Bevers et al., “Changes in Membrane Phospholipid Distribution During Platelet Activation”,Biochim. Biophys. Acta., 736:57-66, 1983.
Bitbol et al., “Ion Regulation of Phosphatidylserine and Phosphatidylethanolamine Outside-Inside Translocationin Human Erythrocytes”,Biochem. Biophys. Acta., 904(2):268-282, 1987.
Hashimoto et al., “Antibody-Dependent Cell Mediated Cytotoxicity Against Influenza Virus-Infected Cells”,J. Infect. Dis., 148:785, 1983.
Lucia etal., “The Effect of an Arenavirus Infection on Liver Morphology and Function”,Am. J. Trop. Med. Hyg., 43(1):93-98, 1990.
Murphy et al., “Arenaviruses in Vero Cells: Ultrastructural Studies”,J. Virol., 6:507, 1970.
Rao et al., “Binding of Annexin V to a Human Ovarian Carcinoma Cell Line (OC-2008), Contrasting Effects on Cell Surface Factor VIIa/Tissue Factor Activity and Prothrombinase Activity”,Thromb. Res., 67(5):517-531, 1992.
Rote et al., “Expression of Phosphatidylserine-Dependent Antigens on the Surface of Differentiating BeWo Human Choriocarcinoma Cells”,Am. J. Rep. Immunol., 33:114-121, 1995.
Takizawa et al., “Induction of Programmed Cell Death (Apoptosis) by Influenza Virus Infection in Tissue Culture Cells”,J. Gen. Virol., 74:2347-2355, 1993.
Utsugi et al., “Elevated Expression of Phosphatidylserine in the Outer Membrane Leaflet of Human Tumor Cells and Recognition by Activated Human Blood Monocytes”,Cancer Res., 51:3062-3066, 1991.
Adler et al., “Monoclonal Antiphosphatidylserine Antibody Inhibits Intercellular Fusion of the Choriocarcinoma Line, JAR”,Biology of Reproduction, 53:905-910, 1995.
Ahola et al., “Semliki Forest Virus mRNA Capping Enzyme Requires Association with Anionic Membrane Phospholipids for Activity”,EMBO J., 18(11):3164-3172, 1999.
Aussel et al., “Monoclonal Antibodies Directed Against the E2 Protein (MIC2 Gene Product) Induce Exposure of Phosphatidylserine at the Thymocyte Cell Surface”,Biochemistry, 32:10096-10101, 1993.
Balachandran et al., “Protection Against Lethal Challenge of BALB/c Mice by Passive Transfer of Monoclonal Antibodies to Five Glycoproteins of Herpes Simplex Virus Type 2”,Infect. Immun., 37(3):1132-1137, 1982.
Banki et al., “Molecular Ordering in HIV-Induced Apoptosis”,J. Biol. Chem., 273(19):11944-11953, 1998.
Beck et al., “Combination of a Monoclonal Anti-Phosphatidylserine Antibody with Gemcitabine Strongly Inhibits the Growth and Metastasis of Orthotopic Pancreatic Tumors in Mice”,Int. J. Cancer, 118:2639-2643, 2006.
Bombeli et al., “Apoptotic Vascular Endothelial Cells Become Procoagulant”,Blood, 89(7):2429-2442, 1997.
Bondanza et al., “Inhibition of Phosphatidylserine Recognition Heightens the Immunogenicity of Irradiated Lymphoma Cells In Vivo”,J. Exp. Med., 200(9):1157-1165, 2004.
Boyle et al., “Endothelial Cell Injury in Cardiovascular Surgery: Ischemia-Reperfusion”,Ann. Thorac. Surg., 62:1868-1875, 1996.
Buckland and Wilton, “Anionic Phospholipids, Interfacial Binding and the Regulation of Cell Functions”,Biochim. Biophys. Acta, 1483:199-216, 2000.
Chejanovsky et al., “Membrane Vesicles Containing the Sendai Virus Binding Glycoprotein, but not the Viral Fusion Protein, Fuse with Phosphatidylserine Liposomes at Low pH”,Biochemistry, 25:4810-4817, 1986.
Chen et al., “Phosphatidylserine Regulates the Maturation of Human Dendritic Cells”,J. Immunol., 173:2985-2994, 2004.
Coll, “Synthetic Peptides from the Heptad Repeats of the Glycoproteins of Rabies, Vesicular Stomatitis, and Fish Rhabdoviruses Bind Phosphatidylserine”,Arch. Virol., 142:2089-2097, 1997.
Conti et al., “Role of Membrane Phospholipids and Glycolipids in Cell-to-Cell Fusion by VSV”,Comp. Immun. Microbiol. Infect. Dis., 14(4):303-313, 1991.
de Bruin et al., “Species Specificity for HBsAg Binding Protein Endonexin II”,J. Hepatology, 24:265-270, 1996.
Estepa and Coll, “Phosphatidylserine Binding to Solid-Phase Rhabdoviral Peptides: A New Method to Study Phospholipid/Viral Protein Interactions”,J. Virological Methods, 61:37-45, 1996.
Estepa et al., “A Protein G Fragment from the Salmonid Viral Hemorrhagic Septicemia Rhabdovirus Induces Cell-to-Cell Fusion and Membrane Phosphatidylserine Translocation at Low pH”,J. Biol. Ch
Ran Sophia
Soares M. Melina
Thorpe Philip E.
LandOfFree
Combinations kits and methods for treating viral infections... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinations kits and methods for treating viral infections..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations kits and methods for treating viral infections... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2680824