Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-12-28
1983-10-18
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
A61K 3702
Patent
active
044105126
ABSTRACT:
Novel combinations comprising (a) at least one peptide having the following amino acid sequence ##STR1## wherein X.sub.1, X.sub.2, and X.sub.3 are selected from a group consisting of N-terminal and desamino alpha-carbon substitutions and a and b are 0 or 1, provided that a and b are always 0 when A.sub.1 is a desamino residue; A.sub.1 and A.sub.4 are selected from a group consisting of histidyl, arginyl, lysyl, .alpha.-naphthylalanyl, .beta.-naphthylalanyl, isoquinolyl, tyrosyl, tryptophyl, phenylalanyl, homologues and anlogues thereof, and, with respect to A.sub.1 only the desamino forms thereof; A.sub.2 and A.sub.5 are selected from a group consisting of D-histidyl, D-arginyl, D-lysyl, D-.alpha.-naphthylalanyl, D-.beta.-naphthylalanyl, D-isoquinolyl, D-tyrosyl, D-tryptophyl, D-phenyalanyl, homologues and analogues thereof; A.sub.3 is selected from a group consisting of glycyl, alanyl, valyl, leucyl, isoleucyl, prolyl, seryl, threonyl, methionyl, aspartyl, glutamyl, asparginyl, glutaminyl, histidyl, D-alanyl, D-valyl, D-leucyl, D-isoleucyl, D-prolyl, D-seryl, D-threonyl, D-methionyl, D-aspartyl, D-glutamyl, D-asparaginyl, D-glutaminyl, D-histidyl, and homologues and analogues thereof; A.sub.6 is selected from a group consisting of amino acids of the L- and D- configuration, homologues and analogues thereof, and the decarboxy forms thereof; and Y is selected from a group consisting of C-terminal and descarboxy alpha-carbon substitutions; and the pharmaceutically acceptable salts thereof; and (b) a growth promoting agent.
REFERENCES:
patent: 3239345 (1966-03-01), Hodge et al.
patent: 4036979 (1977-07-01), Asato
patent: 4223020 (1980-09-01), Momany
patent: 4223021 (1980-09-01), Momany
patent: 4224316 (1980-09-01), Momany
patent: 4226857 (1980-10-01), Momany
patent: 4228155 (1980-10-01), Momany
patent: 4228156 (1980-10-01), Momany
patent: 4228157 (1980-10-01), Momany
patent: 4228158 (1980-10-01), Momany
Beckman Instruments Inc.
Frieman Robert S.
Moezie F. T.
Phillips Delbert R.
Steinmeyer Robert J.
LandOfFree
Combinations having synergistic pituitary growth hormone releasi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combinations having synergistic pituitary growth hormone releasi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combinations having synergistic pituitary growth hormone releasi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1289208