Combinations for the treatment of diseases involving...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S418000, C514S227200, C544S253000

Reexamination Certificate

active

07087627

ABSTRACT:
Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or action of nitric oxide in mammalian systems. There are also provided the use of said combinations in medicaments and kits of said compounds and treatment employing said materials.

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Effect of the Tumor Vascular-Damaging Agent, ZD6126, on the Radioresponse of U87. Glioblastoma: Clinical Cancer Research vol. 11 835-842, 2005: Phyllis R. Wachsberger, Randy Burd, nichol Marero, Constantine Daskalakis, Anderson Ryan, Peter McCue, Adam P. Dicker.
Annex A—Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues: Tozer, Prise, Wilson, Locke, Vojnovic, Stratford, Dennis, Chaplin: Cancer Research 59, 1626-1634, Apr. 1, 1999.
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