Combinations and methods for reducing antimicrobial resistance

Details Combinations and methods for reducing antimicrobial resistance Combinations and methods for reducing antimicrobial resistance

1994-12-27

1999-02-16

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 30, 514 35, 514 46, A61K 3170

Patent

active

058721045

ABSTRACT:
Disclosed are novel methods, combinations of agents and kits for use in killing, or inhibiting the growth of, microorganisms. Enhanced antimicrobial action is provided by using a methylation inhibitor, as exemplified by using an agent that inhibits methylation or maturation of bacterial RNA in combination with, e.g., a macrolide lincosamide streptogramin B (MLS) antibiotic. The methods and compositions described may be employed to reduce the resistance of susceptible microorganisms to antimicrobial agents and thus to treat animals or patients with infections.

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Hasobe et al, "The Synergism of Nucleoside Antibiotics Combined with Guanine 7-N-Oxide Against a Rhabdovirus, Infectious Hematopoietic Necrosis Virus (IHNV)," The Journal of Antibiotics, vol. 39, No. 9, 1291-1297, 1986.
Kovacs, et al,"Potent Effect of Trimetrexate, a Lipid-Soluble Antigolate, on Toxoplasma gondii," The Journal of Infectious Diseases, vol. 155, No. 5, 1028-1032, May 1987.
Touze, J.E.,"Actualites Et Renouveau En Therapeutique Anti-Parasitaire," La Presse Medicale, vol. 23, No. 26, 1195-1198, Sep. 3-10, 1994.

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