Combination therapy using immunotoxins with interleukin-2

Details Combination therapy using immunotoxins with interleukin-2 Combination therapy using immunotoxins with interleukin-2

1987-12-09

1989-09-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 858, 424 8591, 514 2, 514 8, 514 21, 514885, 530351, 530389, 530391, A61K 3702

Patent

active

048637262

ABSTRACT:
Anti-tumor activity in humans can be augmented by administering to the mammalian host a pharmacologically effective amount of mammalian IL-2 and at least one immunotoxin that binds selectively to human tumor cells. The IL-2 and immunotoxin are preferably administered separately to the host. The composition is useful for prophylactic or therapeutic treatment of such cancers as ovarian and breast cancer.

REFERENCES:
patent: 4604377 (1986-08-01), Fernandes et al.
Dr. Rosenstein et al., J. Immunol. (1986), 137:1735-1742.
Shaw et al., Cell Immunol. (1985), 91:193-200.
Shaw et al., Cell Immunol. (1985), 90:547-554.
Nonomura et al., Hepatology (1984), 4:1087.
Kimber et al., J. Clin. Lab. Immunol. (1984), 15:77-84.
Lotze et al., J. Immunol. (1985), 135:2865.

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