Combination therapy using antitumor immunotoxins with tumor necr

Details Combination therapy using antitumor immunotoxins with tumor necr Combination therapy using antitumor immunotoxins with tumor necr

1987-03-02

1990-01-16

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 859, 514 2, 514 8, 514 21, 514885, 530351, 530391, A61K 3702, A61K 3900, A61K 39395

Patent

active

048942251

ABSTRACT:
Tumor necrosis factor and a suitable immuotoxin when administered simultaneously or in tandem produce a synergistic effect in treating tumor burden in warm-blooded animals. Methods and protocols for obtaining this syneristic effect are disclosed, as well as compositions effective in this treatment.

REFERENCES:
patent: 4650674 (1987-03-01), Aggarwal et al.
Winkelhake et al., CA vol. 107 (11) #95043f.
Hadden, "The Case for Synergistic Combinations in Immunotherapy", 14th International Cancer Congress 8/21-27/86.
Dr. Talmadge, Preclinical Screening Lab, BRMP (1986).

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