Combination therapy to treat osteoporosis - polyphosphonates and

Details Combination therapy to treat osteoporosis - polyphosphonates and Combination therapy to treat osteoporosis - polyphosphonates and

1997-02-21

1998-06-30

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514102, 514108, A61K 31135, A61K 3166

Patent

active

057734771

ABSTRACT:
The present invention provides novel methods of treating or preventing osteoporosis comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof; together with a bone resorption inhibiting polyphosphonate.

REFERENCES:
patent: 3683080 (1972-08-01), Francis
patent: 5047431 (1991-09-01), Schickaneder et al.
patent: 5254594 (1993-10-01), Niikura et al.
patent: 5384332 (1995-01-01), Fontana
patent: 5441986 (1995-08-01), Thompson
patent: 5455275 (1995-10-01), Fontana
patent: 5550164 (1996-08-01), Fontana
U.S. Pharmacopeia, 12601 Twinbrook Parkway, Rockville, Maryland, 30 (1998).

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