Combination therapy to prevent bone loss-progesterone and estrog

Details Combination therapy to prevent bone loss-progesterone and estrog Combination therapy to prevent bone loss-progesterone and estrog

1998-11-16

2000-05-02

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514648, A61K 3156, A61K 31135

Patent

active

060573090

ABSTRACT:
The present invention provides novel methods of inhibiting bone loss comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different provided that, when R.sup.1 and R.sup.2 are the same, each is a methyl or ethyl group, and, when R.sup.1 and R.sup.2 are different, one of them is a methyl or ethyl group and the other is hydrogen or a benzyl group; or a pharmaceutically acceptable salt thereof; together with a progestin.

REFERENCES:
patent: 5047431 (1991-09-01), Schickaneder et al.
patent: 5254594 (1993-10-01), Niikura et al.
patent: 5384332 (1995-01-01), Fontana
patent: 5441986 (1995-08-01), Thompson
patent: 5455275 (1995-10-01), Fontana
patent: 5550164 (1996-08-01), Fontana
Patent Abstract of Japan, vol. 095, No. 002, Mar. 31, 1995.
Hasmann, et al., Cancer Letters, vol. 84(2), pp. 101-116 (1994).

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