Combination therapy for treating, preventing, or reducing the ri

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514165, 514161, 514162, 514248, 514249, 514252, 514253, 514254, 514332, 514333, 514334, 514335, 514354, 514357, 514367, 514368, 514378, 514393, 514394, 514403, 514406, 514415, 514424, 514438, 514468, 514473, 514534, 514538, 514540, 514542, 514551, 514601, 514602, 514603, 514605, 514922, 514301, 514258, A61K 3144, A01N 4106, A01N 4378

Patent

active

061368040

ABSTRACT:
The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis, transient ischemic attack, and first or subsequent thrombotic stroke, in a patient, comprising administering to the patient a therapeutically effective amount of an antiplatelet agent in combination with a therapeutically effective amount of a COX-2 inhibitor. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a COX-2 inhibitor, or a pharmaceutically acceptable salt thereof, and an antiplatelet agent, or a pharmaceutically acceptable salt thereof.

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patent: 5800385 (1998-09-01), Demopulos et al.
Busch, U., et al., "Interaction of Meloxicam with Cimetidine, Maalox, or Aspirin," J. Clin. Pharmacol., vol. 36, pp. 79-84 (1996).
Ridker, P. M., et al., "Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men," The New England Journal of Medicine, vol. 336, No. 14, (1997) pp. 973-979.
Talley, J. J., "Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis--Selective Inhibitors of Cyclooxygenase-2," Exp. Opin. Ther. Patents, 7(1), (1997) pp. 55-62.
"Use of a Monoclonal Antibody Directed Against the Platelet Glycoprotein IIb/IIIa Receptor in . . . ," The New England Journal of Medicine, vol. 330, No. 14, pp. 956-961 (1994).

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