Combination therapy for the treatment of heart failure

Details Combination therapy for the treatment of heart failure Combination therapy for the treatment of heart failure

2005-09-27

2005-09-27

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S411000, C514S620000, C514S651000, C514S653000

Reexamination Certificate

active

06949548

ABSTRACT:
A combination therapy for the treatment of heart failure comprises administering a combination of levosimendan or a pharmaceutically acceptable salt thereof and a beta-adrenergic receptor antagonist to a patient. The combination synergistically reduces mortality in heart failure patients.

REFERENCES:
patent: WO 92/12135 (1992-07-01), None
patent: WO 98/58638 (1998-12-01), None
John G.F. Cleland et al., “Levosimendan: a new era for inodilator therapy for heart failure?,” Current Opinion in Cardiology, vol. 17, No. 3, pp. 257-265, May 2002.
Heimo Haikala et al., “The role of cAMP- and cGMP-dependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan,” Cardiovascular Research, vol. 34, No. 3, 1997, pp. 536-546.
Katalin György et al., “Haemodynamic effects of intravenous levosimendan during oral metroprolol treatment in anesthetized dogs,” Journal of Molecular and Cellular Cardiology, vol. 29, No. 5, 1997, p. A127, col. Sa 81.
David P. Figgitt et al., “Levosimendan”, Drugs, vol. 61, No. 5, Mar. 2001, pp. 613-627.
A. Lochner et al., “Effect of a Calcium-Sensitizing Agent, Levosimendan, on the Postcardioplegic Inotropic Response of the Myocardium,” Cardiovascular Drugs and Therapy, vol. 14, No. 3, 2000, pp. 271-281.
Nicolai Gruhn et al., “Coronary Vasorelaxant Effect of Levosimendan, a New Inodilator with Calcium-Sensitizing Properties,” Journal of Cardiovascular Pharmacology, vol. 31, No. 5, 1998, pp. 741-749.
Mara T. Slawsky, MD, PhD. et al., “Acute Hemodynamic and Clinical Effects of Levosimendan in Patients with Severe Heart Failure,” Circulation, vol. 102, No. 18, 2000, pp. 2222-2227.

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