Combination therapy for the treatment of Alzheimer's disease

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C424S140100, C424S278100, C604S006010

Reexamination Certificate

active

07935348

ABSTRACT:
The invention relates to a method for treating Alzheimer's disease by inducing sequestration of amyloid β into a plasma with a Aβ-mimotope peptide, and treatment with an apheresis device such that a fixed carrier can come into contact with the blood or plasma flow and includes a receptor that binds to an amyloid-β precursor-protein (APP), the APP being removed from the blood with the apheresis device.

REFERENCES:
patent: 6551266 (2003-04-01), Davis, Jr.
patent: 2007/0026029 (2007-02-01), Mattner et al.
patent: 00 72880 (2000-12-01), None
patent: 03 000719 (2003-01-01), None
patent: 03 051374 (2003-06-01), None
patent: 2004 013172 (2004-02-01), None
patent: 2004 056318 (2004-07-01), None
patent: 2004 062556 (2004-07-01), None
patent: 2005 025651 (2005-03-01), None
patent: 2006 005707 (2006-01-01), None
Janus C et al. A beta peptide immunization reduces behavioral impairment and plaques in a model of Alzheimer's disease. Nature, 2000; 408:979-982.
Morgan D et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 2000; 408:982-985.
Perrin RJ et al. Multimodal techniques for diagnosis and prognosis of Alzheimer's disease. Nature, Oct. 2009; 461(7266):916-922.
Solomon B. Immunological approaches as therapy for Alzheimer's disease. Expert Opin. Biol. Ther. 2002; 2(8):907-917.
Vickers JC. A vaccine against Alzheimer's disease: developments to date. Drugs Aging. 2002; 19(7):487-494.
J. McLaurin, et al., “Therapeutically Effective Antibodies Against Amyloid-Beta Peptide Target Amyloid-Beta Residues 4-10 and Inhibit Cytotoxicity and Fibrillogenesis” Nature Medicine, vol. 8, No. 11, XP 002288573, pp. 1263-1269, 2002.
Frank L. Heppner, et al., “Current Concepts and Future Prospects for Alzheimer Disease Vaccines”, Alzheimer Disease and Associated Disorders, vol, 18, No. 1, XP 008057356, pp. 38-43, 2004.
Ulrich Reineke, et al., “Identification of Distinct Antibody Epitopes and Mimotopes From a Peptide Array of 5520 Randomly Generated Sequences”, Journal of Immunological Methods, vol. 267, No. 1, XP 004372978, pp. 37-51, 2002.
Frederique Bard, et al., “Peripherally Administered Antibodies Against Amyloid Beta-Peptide Enter the Central Nervous System and Reduce Pathology in a Mouse Model of Alzheimer Disease”, Nature Medicine, vol. 6, No. 8, pp. 916-919, 2000.
Dale Schenk, et al., “Immunization With Amyloid-Beta Attenuates Alzheimer-Disease-Like Pathology in the PDAPP Mouse”, Letters to Nature, vol. 400, pp. 173-177, 1999.
Christoph Hock, et al., “Generation of Antibodies Specific for Beta-Amyloid by Vaccination of Patients With Alzheimer Disease”, Nature Medicine, vol. 8, No. 11, pp. 1270-1275, 2002.
U.S. Appl. No. 12/752,451, filed Apr. 1, 2010, Mattner.

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