Combination therapy for the treatment of acute leukemia and...

Details Combination therapy for the treatment of acute leukemia and... Combination therapy for the treatment of acute leukemia and...

2007-06-11

2010-06-01

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S181100, C514S045000, C514S049000

Reexamination Certificate

active

07727968

ABSTRACT:
Methods of treatment and pharmaceutical combinations are provided for the treatment of acute leukemia, such as acute myelogenous leukemia, and myelodysplastic syndrome. The methods of treatment and pharmaceutical combinations employ an anti-CD33 cytotoxic conjugate in combination with at least one compound selected from the group consisting of an anthracycline and a pyrimidine or purine nucleoside analog. Preferred methods of treatment and pharmaceutical combinations employ gemtuzumab ozogamicin, daunorubicin, and cytarabine.

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patent: 2002/0103141 (2002-08-01), McKearn et al.
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Mark H. Beers and Robert Berkow, The Merck Manual, Seventeenth Edition, Sec. 11, Ch. 138, pp. 945-955, (1999).
G. Garcia-Manero, et al, Myelodyplastic Syndromes Acute Myeloid Leukemia, Haematologica, vol. 87(8): 804-807 Aug. 2002.
Elihu H. Estey, et al., Gemtuzumab Ozogamicin With or Without Interleukin 11 in Patients 65 Years of Age or Older With Untreated Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome: Comparison With Idarubicin Plus Continuous-Infusion, High-Dose Cytosine Arabinoside, Blood, vol. 99(12), pp. 4343-4349, Jun. 2002.

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