Combination therapy for androgenic alopecia with antisense oligo

Details Combination therapy for androgenic alopecia with antisense oligo Combination therapy for androgenic alopecia with antisense oligo

1997-04-14

1999-11-30

Marschel, Ardin H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 514 2, 436501, A61K 4800

Patent

active

059943190

ABSTRACT:
Minoxidil has been shown to stimulate hair growth or inhibit the loss of hair in a number of patients beginning to develop androgenic alopecia. The mechanism by which minoxidil (2,4-pyrimidinediamine, 6-(1-piperidinyl)-3-oxide) alters the hair growth cycle is uncertain, but is thought to act by increasing vascular circulation to the hair follicle. Inhibitors of steroid metabolism, particularly those that inhibit the conversion of testosterone to dihydrotestosterone, have shown effects on hair cycles, including inhibition of hair loss. One class of enzymes targeted by these inhibitors are the steroid 5-alpha reductases. Minoxidil used in conjunction with effectors of steroid metabolism, leads to enhanced hair growth and decreased rates of hair loss. This specification relates to the use of antisense oligonucleotides targeting 5-alpha reductases used in conjunction with other hair growth enhancers and/or hair loss inhibitors.

REFERENCES:
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"Finasteride Merck & Co submitted for approval", R&D Focus Drug News, Apr. 7, 1997.
"Merck & Co's Propecia Shows Promise in Hair Loss", Marketletter, Mar. 31, 1997.

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