Combination therapy employing ileal bile acid transport...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S009000

Reexamination Certificate

active

06943189

ABSTRACT:
Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.

REFERENCES:
patent: 3262850 (1966-07-01), Glynne
patent: 3287370 (1966-11-01), Mohrbacher
patent: 3389144 (1968-06-01), Mohrbacher
patent: 3520891 (1970-07-01), Mohrbacher
patent: 3674836 (1972-07-01), Creger
patent: 3692895 (1972-09-01), Nelson
patent: 3694446 (1972-09-01), Houlihan et al.
patent: 3714190 (1973-01-01), Boissier
patent: 3781328 (1973-12-01), Witte
patent: 3948973 (1976-04-01), Phillips
patent: 3962261 (1976-06-01), Zinnes
patent: 3972878 (1976-08-01), Schirmann
patent: 3983140 (1976-09-01), Endo
patent: 4002750 (1977-01-01), Ambrogi
patent: 4058552 (1977-11-01), Mieville
patent: 4185109 (1980-01-01), Rosen
patent: 4231938 (1980-11-01), Monaghan
patent: 4251526 (1981-02-01), McCall
patent: 4346227 (1982-08-01), Terahara
patent: 4410629 (1983-10-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4559332 (1985-12-01), Grob
patent: 5075293 (1991-12-01), Reifschneider
patent: 5153184 (1992-10-01), Reifschneider
patent: 5158943 (1992-10-01), Sohda
patent: 5244887 (1993-09-01), Straub
patent: 5260316 (1993-11-01), Van Duzer
patent: 5334600 (1994-08-01), Van Duzer
patent: 5350761 (1994-09-01), Van Duzer
patent: 5354772 (1994-10-01), Kathawala
patent: 5430116 (1995-07-01), Kramer
patent: 5502045 (1996-03-01), Miettinen
patent: 5512558 (1996-04-01), Enhsen
patent: 5519001 (1996-05-01), Kushwaha et al.
patent: 5602152 (1997-02-01), Berthelon
patent: 5610151 (1997-03-01), Glombik
patent: 5663165 (1997-09-01), Brieaddy
patent: 5703188 (1997-12-01), Mandeville
patent: 5705524 (1998-01-01), McGee
patent: 5723458 (1998-03-01), Brieaddy
patent: 5767115 (1998-06-01), Rosenblum
patent: 5929062 (1999-07-01), Haines
patent: 5994391 (1999-11-01), Lee
patent: 6020330 (2000-02-01), Enhsen
patent: 6034118 (2000-03-01), Bischofberger
patent: 6268392 (2001-07-01), Keller et al.
patent: 6337327 (2002-01-01), Tuffin et al.
patent: 6355672 (2002-03-01), Yasuma et al.
patent: 6376537 (2002-04-01), Weinberg
patent: 6384034 (2002-05-01), Simitchieva et al.
patent: 6420417 (2002-07-01), Keller et al.
patent: 6441022 (2002-08-01), Frick et al.
patent: 6441029 (2002-08-01), Elson
patent: 6455574 (2002-09-01), Buch
patent: 6462091 (2002-10-01), Keller et al.
patent: 6642268 (2003-11-01), Keller et al.
patent: A-30209/92 (1992-12-01), None
patent: A-61946/94 (1994-06-01), None
patent: A-61948/94 (1994-06-01), None
patent: A-61949/94 (1994-06-01), None
patent: 2025294 (1991-03-01), None
patent: 2078588 (1993-03-01), None
patent: 2085782 (1993-06-01), None
patent: 2085830 (1993-06-01), None
patent: 1211258 (1968-02-01), None
patent: 196 27 430 (1996-08-01), None
patent: 3 122 499 (1999-02-01), None
patent: 0 067 086 (1982-10-01), None
patent: 0 129 748 (1985-02-01), None
patent: 0 250 265 (1987-06-01), None
patent: 0 338 331 (1989-06-01), None
patent: 0 379 161 (1990-01-01), None
patent: 0 531 901 (1992-02-01), None
patent: 0 508 425 (1992-09-01), None
patent: 0 549 967 (1992-12-01), None
patent: 0 526 402 (1993-02-01), None
patent: 0 559 064 (1993-02-01), None
patent: 0 563 731 (1993-03-01), None
patent: 0 568 898 (1993-04-01), None
patent: 0 818 197 (1997-06-01), None
patent: 0 818 448 (1997-06-01), None
patent: 0 796 846 (1997-07-01), None
patent: 0 801 060 (1997-10-01), None
patent: 0 409 281 (2000-04-01), None
patent: 0 244 364 (2002-05-01), None
patent: 0 033 538 (2002-06-01), None
patent: 0 022 487 (2002-07-01), None
patent: 2 661 676 (1990-02-01), None
patent: 2 305 665 (1997-04-01), None
patent: 2 329 334 (1999-03-01), None
patent: 1 211 258 (2000-01-01), None
patent: 2 077 264 (2000-02-01), None
patent: 10-287662 (1998-10-01), None
patent: 89/01477 (1989-02-01), None
patent: 91/08205 (1991-06-01), None
patent: 92/17467 (1992-10-01), None
patent: 92/18115 (1992-10-01), None
patent: 92/18462 (1992-10-01), None
patent: 93/16055 (1993-08-01), None
patent: 93/21146 (1993-10-01), None
patent: 94/18183 (1994-08-01), None
patent: 94/18184 (1994-08-01), None
patent: 94/24087 (1994-10-01), None
patent: 95/21843 (1995-08-01), None
patent: 96/05188 (1996-02-01), None
patent: 96/08484 (1996-03-01), None
patent: 96/16051 (1996-05-01), None
patent: 96/40255 (1996-12-01), None
patent: 97/03953 (1997-02-01), None
patent: 97/33882 (1997-09-01), None
patent: 97/49387 (1997-12-01), None
patent: 97/49736 (1997-12-01), None
patent: 98/02432 (1998-01-01), None
patent: 98/06405 (1998-02-01), None
patent: 98/23593 (1998-06-01), None
patent: 98/35937 (1998-08-01), None
patent: WO 98/38182 (1998-08-01), None
patent: 98/38182 (1998-09-01), None
patent: 98/39299 (1998-09-01), None
patent: WO 98/40375 (1998-09-01), None
patent: 98/40375 (1998-09-01), None
patent: 98/56757 (1998-12-01), None
patent: 99/11259 (1999-03-01), None
patent: 99/11260 (1999-03-01), None
patent: 99/11263 (1999-03-01), None
patent: 99/14174 (1999-03-01), None
patent: 99/14204 (1999-03-01), None
patent: 99/14215 (1999-03-01), None
patent: 99/32478 (1999-07-01), None
patent: 99/35135 (1999-07-01), None
patent: 99/64409 (1999-12-01), None
patent: 00/35889 (2000-06-01), None
A. Barrett et al., “Total Synthesis and Stereochemical Assignment of the Quinquecyclopropane-Containing Cholesteryl Ester Transfer Protein Inhibitor U-106305”, J. Am Chem. Soc., 1996, 118, pp. 7863-7864.
P. Barter et al. “High Density Lipoproteins and Coronary Heart Disease”, Atherosclerosis, 121 1996, pp. 1-12.
A. Beckwith et al., “Iododediazoniation of Arenediazonium Salts Accompanied by Aryl Radical Ring Closure” J. Org. Chem. 1987, vol. 52, pp. 1922-1930.
D. Bilheimer et al., “Mevinolin and Colestipol Stimulate Receptor-Mediated Clearance of Low Density Lipoprotein From Plasma In Familial Hypercholesterolemia Heterzygotes”, Proc. Natl. Acad. Sci. USA, vol. 80, Jul. 1983, pp. 4124-4128.
C. Bisgaier et al., Cholesteryl Ester Transfer Protein Inhibition By PD 140195, Lipids, vol. 29, No. 12, 1994, pp. 811-818.
D. Blankenhorn et al., “Beneficial Effects of Combined Colestipol-Niacin Therapy On Coronary Atherosclerosis and Coronary Venous Bypass Grafts”, JAMA, Jun. 19, 1987, vol. 257, No. 23, pp. 3233-3240.
D. Blankenhorn et al., “Beneficial Effects of Colestipol-Niacin Therapy on the Common Carotid Artery” Circulation vol. 88, Jul. 1, 1993, pp. 20-28.
P. Bonin et al., “A Peptide Inhibitor Of Cholesteryl Ester Transfer Protein Identified By Screening a Bacteriophage Display Library”, Journal of Peptide Research, 51, 1998, pp. 216-225.
G. Brown, et al., “Regression of Coronary Artery Disease As A Result of Intensive Lipid-Lowering Therapy in Men With High Levels Of Apolipoprotein B”, The New England Journal of Medicine, vol. 323, Nov. 8, 1990, No. 19, pp. 1289-1339.
M. Brown et al., Induction of 3-hydroxy-3Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts Incubated with Compactin (ML-236B), A Competitive Inhibitor of the Reductase, The Journal of Biological Chemistry, vol. 253, No. 4, Feb. 22, 1978, pp. 1121-1128.
S. Busch et al., “Cholesteryl Ester Analogs Inhibit Cholesteryl Ester But Not Triglyceride Transfer Catalyzed By The Plasma Cholesteryl Ester-Triglyceride Transfer Protein”, Lipids, vol. 25, No. 4 (1990), pp. 216-220.
C. Camoutsis et al., “N-Substituted 4,5-Dihydro-1,2-Benzothiazepin-3-One, 1, 1-Dioxide”, J. Heterocyclic Chem. 17, pp. 1135-1136 (1980).
L. Cashin-Hemphill et al., “Beneficial Effects of Colestipol-Niacin on Coronary Atherosclerosis A 4-Year Follow-up”, JAMA, Dec. 19, 1990, vol. 264, No. 23, pp. 3013-3017

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