Combination therapy comprising glucose reabsorption...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S003100, C514S365000, C514S369000, C514S451000, C514S457000, C514S866000

Reexamination Certificate

active

06838442

ABSTRACT:
Combination therapy comprising RXR modulators and glucose reabsorption inhibitors useful for the treatment of diabetes and Syndrome X are disclosed.

REFERENCES:
patent: 5424406 (1995-06-01), Tsujihara et al.
patent: 5731292 (1998-03-01), Tsujihara et al.
patent: 5731299 (1998-03-01), Ebetino et al.
patent: 5767094 (1998-06-01), Tsujihara et al.
patent: 5830873 (1998-11-01), Tsujihara et al.
patent: 6048842 (2000-04-01), Tsujihara et al.
patent: 6153632 (2000-11-01), Rieveley
patent: 6515003 (2003-02-01), Pfahl et al.
patent: 1 213 296 (2002-08-01), None
patent: WO 9710819 (1997-03-01), None
patent: WO 0061127 (2000-10-01), None
patent: WO 0114372 (2001-03-01), None
patent: WO 0117513 (2001-03-01), None
patent: WO 0174834 (2001-10-01), None
patent: WO 0174835 (2001-10-01), None
Windholz et al., The Merck Index, Tenth Edition (1983) pp. 723 and 724, abstract No. 4866.*
Consoli, Agostino, MD. “Role of Liver in Pathophysiology of NIDDM”, Diabetes Care, vol. 15, No. 3, Mar. 1992 pp 430-441.
Day, C. “Thiazolidinedlones: a new clas of antidiabetic drugs”, Diabetic Medicine, vol. 16, No. 3, 1999, pp. 179-192.
Deetjen, Peter et al. “Renal Handling of D-Glucose and Other Sugars”, 1995 pp. 90-94.
Evans, Alison J. and Krentz, Andrew J., “Recent Developments and Emerging Therapies for Type 2 Diabetes Mellitus”, Drugs R&D 2:Aug. 2, 1999, pp. 75-94.
Freychet, P., “Pancreatic Hormones”. In Hormones from molecules to disease. Kelly, P.A. Baulieu, E.E., eds., Routledge, Chapman and Hall, New York, NY pp. 491-532.
Gerich, J.E., “Role of Liver and Muscle in Type II Diabetes”, Horm. Metab. Res., vol. 26, 1992, pp. 18-21.
Groop, L.C. “Drug treatment of non-insulin-dependent diabetes mellitus” Textbook of Diabetes, Pickup, J.C., Williams, G. eds., Blackwell Science Oxford, UK, 1-18, 1997, pp. 38.1-38.18.
Lee, Wen-Sen et al., “The High Affinity Na+/Glucose Cotransporter”, The Journal of Biological Chemistry, vol. 269, No. 16, Apr. 22, 1994, pp. 12032-12039.
Link, J. T. and Sorensen, Bryan K., “A method for preparing C-glycosides related to phlorizin”, Tetrahedron Letters 41, 2000, pp 9213-9217.
Mackenzie, Bryan et al. “SAAT1 Is a Low Affinity Na +/Glucose Cotransporter and Not an Amino Acid Transporter”, The Journal of Bilogical Chemistry, vol. 269, No. 36, Issue of Sep. 9, 1994, pp 22488-22491.
Oku, Akira et al., “T-1095, an Inhibitor of Renal Na=-Glucose Cotransporters, May Provide a Novel Approach to Treating Diabetes”, Diabetes, vol. 48, Sep. 1999, pp 1794-1800.
Rossetti, Luciano et al., “Correction of Hyperglycemia with Phlorizin Normalizes Tissue Sensitivity to Insulin in Diabetic Rats”, J. Clin. Invest., vol. 79, May 1987, pp. 1510-1515.
Rosetti, Luciano et al., “Glucose Toxicity”, Diabetes Care, vol. 13, No. 6, Jun. 1990 pp 610-630.
Silverman, Mel and Turner James, R., “Glucose transport in the renal proximal tubule”, Chapter 43, Membrane Biology Group, Dept. of Medicine, University of Toronto, Toronto, Ontario, Canada, 1992 pp 2017-2038.
Unger, R.H. and Grundy, S., “Hyperglycaemia as an Inducer as well as a consequence of Impaired islet cell function and insulin resistance: implications for the management of diabetes”, Diabetologia, vol. 28, 1985 pp. 119-121.
You, Guofeng et al., “Molecular Characteristics of Na+-coupled Glucose Transporters in Adult and Embryonic Rat Kidney”, The Journal of Biological Chemistry, vol. 270, No. 49, Issue of Dec. 8, 1995, pp 29365-29371.
PCT International Search Report PCT/US02/10542 dated Jul. 31, 2002.
Buse, J.B., Gumbiner, B. Mathias, N.P.et al. “Troglitazone use in insulin-treated type 2 diabetic patients”; The Troglitazone Insulin study group, Diabetes Care 21: pp. 1455-1461 (1998).
Cha, B.S. et al.; Peroxisome Proliferator-Activated Receptor (PPAR) and Retinoid X Receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle.: Diabetoglogia 44: pp. 444-452 (2001).
Mukherjee, R., Davies, P.J.A., Crombie, D.L., Dischoff, E.D. Cesario, R.M. et al.; “Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists”; Nature 386: pp. 407-410 (1997).
Nestler, J.E., Jakubowicz, D.J., Reamer, P. et al. “Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome”; N. Engl. J. Med. 340: pp. 1314-1320 (1999).
Schwartz, S., Raskin, P., Fonseca, V., and Graveline, J.F. “Effect of troglitazone in insulin-treated patients with type 2 diabetes”; N. Engl. J. Med. 338: pp. 861-866 (1998).
UK Prospective Diabetes Study Group, “Intensive blood-glucose control with sulfphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes”; Lancet 352: pp. 837-853 (1998).
UK Prospective Diabetes Study Group, “Effect of Intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes”, Lancet 352: pp. 854-865 (1998).

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