Combination preparation for use in dementia

Details Combination preparation for use in dementia Combination preparation for use in dementia

1998-02-25

2000-03-14

Gitomer, Ralph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514263, 514297, 514315, 546104, 544267, A61K 3152, A61K 31445, C09B21900, C07D47308, C07D21100

Patent

active

060373474

ABSTRACT:
The invention relates to a composition which is a pharmaceutical combination preparation comprising a compound which has an acetylcholinesterase-inhibitory action or exhibits muscarinergic action and a compound which increases the endogenous extracellular adenosine level, wherein the combination preparation is suitable for the treatment of dementia. The invention further relates to a process for the production of the combination preparation. The invention additionally relates to a process for treating patients in need of suitable therapy with the combination preparation.

REFERENCES:
patent: 3621096 (1971-11-01), Prange, Jr. et al.
patent: 3737433 (1973-06-01), Mohler et al.
patent: 4273774 (1981-06-01), Scherm
patent: 4289776 (1981-09-01), Mohler et al.
patent: 4719212 (1988-01-01), Goto et al.
patent: 4833146 (1989-05-01), Gebert et al.
patent: 5118500 (1992-06-01), Hanel et al.
patent: 5783584 (1998-07-01), Pang et al.
patent: 5837724 (1998-11-01), Allen et al.
Wallis, R.M., Napier C.M., "Muscarinic Antagonists in development for disorders of smooth muscle function," Life-Sci., 64 (6-7), pp. 395-401. Abstract only. (1999).
Choppin, A., Eglen, R.M., Hegde, S.S., "Pharmacological characterization of muscarinic receptors in rabbit isolated iris sphincter muscle and urinary bladder smooth muscle," Br. J. Pharmacol., vol. 124, pp. 883-888. Jul. 1998. Abstract only.
Gillberg, P.G., Sundquist, S., Nilvebrant, L., "Comparison of the in vitro profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists," Eur. J. Pharmacol. (May 1998) vol. 349, pp. 285-292.
Beaumont, K.C., Cussans, N.J., Nichols, D.J., Smith, D.A., "Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man," Xenobiotica, 28 (1), pp. 63-75. Abstract only. (Jan. 1998).
Hegde, S.S., Choppin, A., Bonhaus, D., Briaud, S., Loeb, M., Moy, T.M., Loury, D., Eglen, R.M., "Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo," Br. J. Pharmacol., vol. 120 (8), pp. 1409-18. Abstract only. (Apr. 1997).
Smith, C.M., Wallis, R.M., "Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors," J. Recpt. Signal-Transduct-Res., 17 (1-3), pp. 177-84. (May 1997). Abstract only.
Alabaster, V.A., "Discovery & development of selective M3 antagonists for clinical use," Life-Sci., 60, pp. 1053-60. Abstract only. (1997).
Kaye, B., Herron, W.J., P.V., Robinson, S., Stophe, D.A., Venn, R.F., Wild, W., "Rapid, solid phase extraction technique for the high-throughout assay of darifenacin in human plasma," Anal.Chem., 68(9), pp. 1658-60. (May 1996) Abstract only.
H. Akiyama et al., "Morphological Diversities of CD44 Positive Astrocytes in The Cerebral Cortex of Normal Subjects and Patients with Alzheimer's Disease", Brain Research, 632:249-259 (1993).
H. Tohgi et al., "Remarkable Reduction in Acetylcholine Concentration in the Cerebrospinal Fluid From Patients With Alzheimer Type Dementia", Neuroscience Letters, 177:139-142 (1994).
J. Daly et al., "Adenosine Receptors in the Central Nervous System: Relationship to the Central Actions of Methylxanthines", Life Sciences, 28 (19) :2083-2097 (1981).
M. Ballarin et al., "Extracellular Levels of Adenosine and its Metabolites in the Striatum of Awake Rats: Inhibition of Uptake and Metabolism", Acta Physiol Scand, 142:97-103 (1991).
F. Parkinson et al., "Propentofylline: A Nuceloside Transport Inhibitor with Neuroprotective Effects in Cerebral Ischemia", Gen. Pharmac., 25 (6) :1053-1058 (1994).
E. Messamore et al., "Astrocytes Associated with Senile Plaques Possess Muscarinic Acetylcholine Receptors", NeuroReport, 5 (12) :1473-1476 (Jul. 1994).
Nitahara et al. Neuroscience, 67 (1), pp. 159-168. (Jul. 1995).

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