Combination preparation for contraception based on natural...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S178000, C514S182000

Reexamination Certificate

active

06884793

ABSTRACT:
The combination preparation for contraception includes from 2 to 4 first stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient, from 16 to 22 second stage daily dosage portions each including an effective amount of a combination of at least one natural estrogen and at least one natural or synthetic gestogen as active ingredient; from 2 to 4 third stage daily dosage portions each including an effective amount of at least one natural estrogen as sole active ingredient; and from 2 to 4 final stage daily dosage portions containing a pharmaceutically acceptable placebo. The estrogen may be estradiol, an estradiol compound that is metabolized to estradiol when taken into the body, a conjugated equine estrogen or a phytoestrogen. The natural or synthetic gestogen can be natural progesterone or a synthetic gestogens, such as medroxyprogesterone acetate.

REFERENCES:
English abstract of DE 4308406, CAPLUS, AN1994:491884.*
Darney, P. Safety and efficacy of a triphasic oral contraceptive containing desogestrel: Results of three multicenter trials, EMBASE abstract, AN 93302272, 1993.*
Ehrlich et al. Oral contraceptive, WPIDS abstract AN 1992-269924 (1992).*
New preparation for HRT and oral contraception, WPIDS abstract AN 1995-123225 (1995).*
J.V. Wright, et al: “Comparative Measurements of Serum Estriol, Estradio . . . ”, Altern. Med. Rev. (U.S.), 4 (4), Aug. 1999, pp. 266-270.

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