Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-10-01
1999-07-27
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514211, 514255, 514356, 514654, A61K 31135, A61K 3155, A61K 31495, A61K 3144
Patent
active
059291222
ABSTRACT:
A pharmaceutical combination preparation, particularly for the treatment of pain, which contains a combination of the pain killer tramadol with at least one calcium channel antagonist, and a method of treating pain by administering to a patient suffering therefrom an analgesically effective combination of tramadol and at least one calcium channel antagonist.
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Enrique Contreras, Lya Tamayo and Marco Amigo, "Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance," European Journal of Pharmacology, No. 148 (1988) pp. 463-466.
Esperanza Del Pozo, Gerardo Caro and Jose M. Baeyens, "Analgesic effects of several calcium channel blockers in mice," European Journal of Pharmacology, No. 137 (1988) pp. 155-160.
Bormann et al., "Do Ca-Channel Blockers Have Analgesic Effects?", Fortschr. Anaesth., 1:5-10 (1987).
Jurna et al., "Differential Effects of Morphine and Opioid Analgesics on A and C Fibre-Evoked Activity in Ascending Axons of the Rat Spinal Cord", Brain Research, 171 (1979) 573-576.
Reimann et al., "Spinal Antionciception by Morphine in Rats is Antagonised by Galanin Receptor Antagonists", Archives of Pharmacology, (1994) 350:380-386.
Gruenenthal GmbH
Jarvis William R. A.
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