Combination of tobramycin and fluorometholone for topical ophtha

Details Combination of tobramycin and fluorometholone for topical ophtha Combination of tobramycin and fluorometholone for topical ophtha

1989-11-22

1992-09-22

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514912, A61K 3170

Patent

active

051496933

ABSTRACT:
Disclosed are pharmaceutical compositions comprising tobramycin and fluorometholone or fluorometholone acetate for topical ophthalmic delivery and methods of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.

REFERENCES:
patent: 4407792 (1983-10-01), Schoenwald et al.
patent: 4474753 (1984-10-01), Haslam et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4668506 (1987-05-01), Bawa
Physicians' Desk Reference for Ophthalmology, "MAXIDEX", pp. 81-82 (1989).
Physicians' Desk Reference for Ophthalmology, "MAXITROL", pp. 82-83 (1989).
Physicians' Desk Reference for Ophthalmology, "TOBREX", p. 88 (1989).
Physicians' Desk Reference for Ophthalmology, "FML", pp. 95-97 (1989).
Physicians' Desk Reference for Ophthalmology, "CORTISPORIN", pp. 116-117 (1989).
Physicians' Desk Reference for Ophthalmology, "NEODECADRON", pp. 144-145 (1989).
Schoenwald, R. D., et al., "Ophthalmic Bioequivalence of Steroid/Antibiotic Combination Formulations", Biological Abstracts, vol. 85, 1988, Abstract No. 41064.
Unlisted Drugs, vol. 40, No. 11, Nov. 1988, p. 218, Abstract B: "Tobradex".
Stewart, R. S., et al., "Efficacy and Safety of Tobramycin-Dexamethasone Ophthalmic Suspension Tobradex in Prevention of Infection and Reduction of Inflammation Following Cataract Surgery", Biological Abstracts, Abstract No. 86086941.
Schoenwald, R. D., et al., "Ophthalmic Bioequivalence of Steroid/Antibiotic Combination Formulations", Biopharmaceutics & Drug Disposition, vol. 8, 1987, pp. 527-548.

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