Combination of tobramycin and dexamethasone for topical ophthalm

Details Combination of tobramycin and dexamethasone for topical ophthalm Combination of tobramycin and dexamethasone for topical ophthalm

1989-11-22

1992-09-22

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514912, A61K 3170

Patent

active

051496941

ABSTRACT:
Disclosed are pharmaceutical compositions comprising tobramycin and dexamethasone for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.

REFERENCES:
patent: 4407792 (1984-10-01), Schoenwald et al.
patent: 4474753 (1984-10-01), Haslam et al.
patent: 4478811 (1984-10-01), Haslam et al.
patent: 4668506 (1987-05-01), Bawa
Schoenwald, R. D. et al., "Ophthalmic Bioequivalence of Steroid/Antibiotic Combination Formulations", Biological Abstracts, vol. 85, 1988, Abstract No. 41064.
Unlisted Drugs, vol. 40, No. 11, Nov. 1988, p. 218, Abstract B: "Tobradex".
Stewart, R. S. et al., "Efficacy and Safety of Tobramycin-Dexamethasone Ophthalmic Suspension Tobradex in Prevention of Infection and Reduction of Inflammatin Following Cataract Srgery", Biological Abstracts, Abstract No. 86086941.
Schoenwald, R. D. et al., "Ophthalmic Bioequivalence of Steroid/Antibiotic Combination Formulations", Biopharmaceutics & Drug Disposition, vol. 8, 1987, pp. 527-548.
Physicians' Desk Reference for Ophthalmology, "Maxidex", pp. 81-82 (1989).
Physicians' Desk Reference for Ophthalmology, "Maxitrol", pp. 82-83 (1989).
Physicians' Desk Reference for Ophthalmology, "Tobrex", p. 88 (1989).
Physicians'Desk Reference for Ophthalmology, "FML", pp. 95-97 (1989).
Physicians' Desk Reference for Ophthalmology, "Cortisporin", pp. 116-117 (1989).
Physicians' Desk Reference for Ophthalmology, "Neodecadron", pp. 144-145 (1989).

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