Combination of selective alpha-adrenergic agonists and Na.sup.+

Details Combination of selective alpha-adrenergic agonists and Na.sup.+ Combination of selective alpha-adrenergic agonists and Na.sup.+

1990-12-20

1993-06-01

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514392, 514913, A61K 31495, A61K 31415

Patent

active

052159914

ABSTRACT:
Methods and pharmaceutical compositions of alpha.sub.2 agonists and Na.sup.+ /H.sup.+ exchange inhibitors which are useful in lowering intraocular pressure (IOP) and treatment of intraocular hypertension are disclosed. Co-administration of a therapeutic amount of alpha.sub.2 agonist with a potentiating amount of Na.sup.+ /H.sup.+ exchange inhibitor is effective in lowering IOP and treatment of intraocular hypertension.

REFERENCES:
patent: 3890319 (1975-06-01), Danielewicz et al.
patent: 4400378 (1983-08-01), Innemee et al.
patent: 4515800 (1985-05-01), Cavero et al.
Rouot et al., J. Med. Chemistry 19(8), 1049 (1976).
Simchowitz and Cragoe, Molecular Pharmacology 30, 112 (1986).
Chem. Abst. 109: 32089w (1988).
Chem. Abst. 103: 68755a (1985).

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