Combination of CRP and D-dimer for in vitro diagnosis of...

Details Combination of CRP and D-dimer for in vitro diagnosis of... Combination of CRP and D-dimer for in vitro diagnosis of...

2007-12-11

2007-12-11

Wallenhorst, Maureen M. (Department: 1743)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

C436S063000, C436S518000, C436S533000, C436S811000

Reexamination Certificate

active

10636578

ABSTRACT:
The present invention relates to an in vitro diagnostic method for patients with suspected deep venous thrombosis wherein by combined testing of patients' samples for D-dimer and CRP both the sensitivity and the negative predictive value of DVT diagnostics can be increased up to 100%.

REFERENCES:
Jossang, Bjarne et al. “C-reactive protein & D-dimer in the diagnosis of deep venous thrombosis,” Tidsskrift for den Norske Laegeforening, 1992, vol. 112, No. 9, pp. 1153-1155 (abstract).
Roberts et al. Clinical Chemistry, vol. 46, No. 4, 2000, pp. 461-468.
Janssen et al. (abstract) Thrombosis and Haemostasis, vol. 77, No. 2, Feb. 1997, pp. 262-266.
Bucek, R. et al., “C-reactive protein in the diagnosis of deep vein thrombosis”, British Journal of Haematology, vol. 119, pp. 385-389, (2002).
Horney et al., “Evaluation of analyses to exclude suspected thrombosis. Don't rely on the D-dimer test!”, Lakartidingen. Sweden 7, vol. 95, No. 1-2, pp. 55-58, Jan. 7, 1998.
English-language translation of: B. Jossang et al.,Tidsskr Nor Laegeforen[Journal of the Norwegian Medical Society], 112(9):1153-5 (1992).
M.C.H. Janssen et al.,Thrombosis and Haemostasis77(2): 262-266 (1997).

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