Combination of cholecalciferol derivatives for the treatment of

Details Combination of cholecalciferol derivatives for the treatment of Combination of cholecalciferol derivatives for the treatment of

1987-07-22

1991-03-05

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514167, 514168, A61K 3159

Patent

active

049978241

ABSTRACT:
A method and composition for an improved treatment of human renal osteodystrophy, comprising the administration of 6-40 mcg/d (micrograms per day) of 24,25(OH).sub.2 D.sub.3 in combination with amounts of 1-alpha(OH)D.sub. 3 or 1,25(OH).sub.2 D.sub.3 or DHT.sub.2, which will maintain in the serum of patients the calcium concentration at 10-11 mg/dl (milligrams per deciliter) and the phosphate concentration at 5.5-6.0 mg/dl (milligrams per deciliter) and the numerical multiplication product of calcium x phosphate not more than 60-65.

REFERENCES:
patent: 3715374 (1973-02-01), DeLuca
patent: 4340604 (1982-07-01), Aoki et al.
patent: 4364941 (1982-12-01), Kiyoki et al.
patent: 4442093 (1984-04-01), Maeda et al.
patent: 4590184 (1986-05-01), Maeda et al.
patent: 4628050 (1986-12-01), Maeda et al.
patent: 4866047 (1989-11-01), Yamato et al.
"Treatment of Hemodialysis Bone Disease with 24,25-(OH).sub.2 D.sub.3 and 1,25-(OH).sub.2 D.sub.3 Alone or in Combination" by Dunstan C. R., et al, Mineral Electrolyte Metab. 11:358-368(1985).
"Preliminary Trials with 24,25-Dihydroxyvitamin D.sub.3 in Dialysis Osteomalacia", by Anthony B. Hodsman, et al; Mar. 1983, The American Journal of Medicine, vol. 74, #407.
"24,25(OH).sub.2 D.sub.3 Attenuates the Calcemic Effect of 1,25(OH).sub.2 D.sub.3 in Rats with Reduced Renal Mass" by D. Rubinger, et al, Vitamin D.A. Chemical, Biochemical and Clinical Update, 1985.
Garabedian M., et al, "The In Vitro Production and Activity of 24,25-Dihydroxycholecalciferol in Cartilage and Calvavium, " Clinical Orthopedics and Related Research, Dec. 1978, 241-248.
Statopolsky et al., J. Clin. Invest. 74, 2136 (1984).
Boyle et al, J. Biol. Chem., 248, 4124 (1973).
Popovtzer et al, Clin. Sci., 38, 297 (1970).
Popopovtzer, Int. J. Artif. Org., 3, 1 (1980).
Abstract of Japanese application 5513920 by Teijin.
Kanis et al, "Comparative Physiology and Pharmacology of the Metabolites and Analogues of Vitamin D", Physicians Desk Reference, 40th Edition (1986).
Evans et al, Ibid., p. 302.
Pavlovitch et al, J. Clin. Invest. 68, 803 (1981).
Reeve et al, "Long-term Treatment of Osteoporosis with 24,25-Dihydroxycholecalciferol".
Endo et al, Nature, 286 (1980), 262-264.
Riis et al, "Vit. D-A Chemical Biochemical and Clinical Update", Chemical Abstracts, vol. 89 (1978), 89: 1977 1k.
Physicians' Desk Reference 40th Edition, 1986, p. 1810.
Pierides, Pharmacology and Therapeutic Use of Vitamin D and its Analogues, pp. 244-246.
Is 24,25-Dihydroxycholecalciferol a Calcium-Regulating Hormone in Man? J. A. Kanis, British Medical Journal, May 27, 1978, pp. 1382-1386.
English Language Abstract of EP No. 207,451, p. 64 of Other Organics, Hoff.
Nature, 30, Nov. 1978, pp. 517-519.
Chem. Abstracts, vol. 94, 1981, p. 78.
63-Pharmaceuticals, Chem. Abstr., 103, 92850y 24,25-Dihydroxycholecalci. for Osteoporosis Therapy, p. 325.
B 5 Other Organics, p. 64, EP No. 207-451 A, "Syn.vit.D/compsus.-contg. 1 alpha, 25,-dihydroxylated cholecalciferol cpds."
B 1 Steroids, p. 1, B FARMDOC, J6 1130-225-A, "Analgesic for Renal Osteodys, contains 24,25-di:hydroxy cholecalciferol".
Proc. Nat. Acad. Sci., USA, vol. 70, No. 8, pp. 2248-2252, Aug. 1973, "Biological Activity of 1.alpha.-Hydroxycholecal., A Synthetic Analog of the Hormonal Form of Vit. D.sub.3 ", Haussler et al.
"1.alpha.-Hydroxy Derivative of Vit. D.sub.3 : A Highly Potent Analog of 1.alpha.,25-Dihydroxyvit D.sub.3 ", Science, 180, pp. 190-191.
"Comparison of Effects of 1-Hydroxy-Vit. D.sub.3 and 1,25-Dihydroxy-Vit., D.sub.3 in Man", Brickman et al, J. of Clin. Invest., 57, Jun. 1976, pp. 1540-1547.
Revue d'ensemble, "Le 24,25 dihydroxycholecalciferol a-t-il un role physiologique et physiopathologique? " Sebert et al, Clinique medicale B et Service de Nephrologie, Centre Hospitaller Universitiaire, Amiens, pp. 133-141, 1982.
Serum Concentrations of 24,25-Dihydroxy Vitamin D in Different Degrees of Chronic Renal Failure, British Medical Journal, vol. 281, Sep. 13, 1980, pp. 712-713.
K. Galus et al, Effects of 1-Hydroxyvitamin D.sub.3 and 24R,25-Dihydroxyvitamin D.sub.3 on Bone Remodeling, Calcif. Tissue Int., 31, 209-213 (1980).
B. Lund et al, Treatment of Osteporosis of Ageing with 1.alpha.-Hydroxycholecalciferol, The Lancet, Dec. 13, 1975, pp. 1168-1171.
S. Lawoyin et al, Ability of 25-HydroxyVitamin D.sub.3 Therapy to Augment Serum 1,25-and 24,25-DihydroxyVitamin D in Postmenopausal Osteoporosis, vol. 50, No. 3.
Goodwin et al, 24,25-Dihydroxyvitamin D is a Metabolite of Vitamin D Essential for Bone Formation, Nature, vol. 276, Nov. 30, 1978.
R. A. Donckerwolcke et al, Treatment of Renal Osteodystrophy in Children with Dihydrotachysterol and 24,25 Dihydroxyvitamin D.sub.3, Clin. Nephrol., vol. 24, No. 6-1985, pp. 292-299.
Donald J. Sherrard et al, Use of 24,25 Dihydroxy Vitamin D (OH.sub.2 D), in Renal Osteodystrophy, Abstracts, Fifth Workshop on Vitamin D, Historic Williamsburg, Virginia, Feb. 14-19, 1982.
Jana Henriette Pavlovitch et al, Suppressive Effects of 24,25-Dihydroxycholecalciferol on Bone Resorption Induced by Acute Bilateral Nephrectomy in Rats, J. Clin. Invest., vol. 68, Sep. 1981, pp. 803-810.
B:5 Other Organics, p. 45, Week C50 (Article), Teijin KK, JA-045244.

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