Combination of a potassium channel activator and an antiarrhythm

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514114, 5142355, 514255, 514278, 514302, 514318, 514337, 514392, 514821, A61K 3166, A61K 31535, A61K 31495, A61K 3144, A61K 31445, A61K 31415, A61K 3135

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active

056797060

ABSTRACT:
A method for the concomitant treatment of ischemia and arrhythmia in mammalian species which includes administering a combination of a potassium channel opener having little or no effect on action potential duration in the heart and a class III antiarrhythmic compound.

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Yao et al., "Effects of the K.sub.ATP Channel Opener Bimakalim on Coronary Blood Flow, Monophasic Action Potential Duration, and Infarct Size in Dogs", Cir., vol. 89, No. 4, 1994, pp. 1769-1775.

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