Combination of a hypnotic agent and substituted bis aryl and...

Details Combination of a hypnotic agent and substituted bis aryl and... Combination of a hypnotic agent and substituted bis aryl and...

2008-02-06

2009-11-17

Kwon, Brian-Yong S (Department: 1614)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C514S221000, C514S419000, C514S263100, C514S248000, C514S300000, C514S373000, C514S260100, C514S265100, C514S301000, C514S302000, C514S303000

Reexamination Certificate

active

07618650

ABSTRACT:
The invention concerns the combination of a short-acting hypnotic agent and a compound of formula (I):Wherein X, Y, Z, A, B, D, Ar, R1and R2are as defined herein. The combination of this invention is useful in treating a variety of sleep disorders.

REFERENCES:
patent: 6218547 (2001-04-01), Teuber et al.
patent: 2002/0077332 (2002-06-01), Aronhime et al.
patent: 2004/0258750 (2004-12-01), Alaux et al.
patent: 2007/0265309 (2007-11-01), Eastwood et al.
patent: WO 2006/086705 (2006-08-01), None
Vippagunta et al, “Crystalline Solids”, Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
Gavezzotti, “Are Crystal Structures Predictable?”, Accounts of Chemical Research, vol. 27, pp. 309-314 (1994).

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