Combination of a CB1 receptor antagonist and of a product...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S210160, C514S252120, C514S570000, C514S323000, C514S367000

Reexamination Certificate

active

10786810

ABSTRACT:
The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the pharmaceutical compositions comprising them and to their use in the treatment of Parkinson's disease.

REFERENCES:
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patent: 6355631 (2002-03-01), Achard et al.
Brotchie, J. M., The Cannabinoid Receptor Antagonist SR141716A Reduces L-DOPA- Induced Dyskinesia in the MPTP-Treated Primate Model of Parkinson's Disease, British Journal of Pharmacology (1998, vol. 123, pp. 66P).
Clara Sanudo-Pena et al., A Novel Neurotransmitter System Involved in the Control of Motor Behavior by the Basal Ganglia, Ann. New York Academy of Sciences, (1998, vol. 860, pp. 475-479).
Justin P. Meschler et al., D2, but not D1 Dopamine Receptor Agonists Potentiate Cannabinoid-Induced Sedation In Nonhuman Primates 1,2 Journal of Pharmacology And Experimental Therapeutics, (2000, vol. 292, Issue 3, pp. 952-959).
Vincenzo Di Marzo et al., Enhanced Levels of Endogenous Cannabinoids in the Globus Pallidus are Associated with a Reduction in Movement in an animal model of Parkinson's Disease, FASEB Journal (2000, vol. 14, Issue 10, pp. 1432-1438).

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