Combination of a calcium channel blocker and thromboxane A.sub.2

Details Combination of a calcium channel blocker and thromboxane A.sub.2 Combination of a calcium channel blocker and thromboxane A.sub.2

1988-07-21

1993-02-02

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514469, A01N 4300, A61K 3155

Patent

active

H00011398

ABSTRACT:
A method is provided for treating ischemia in a mammalian species by administering a combination of a calcium channel blocker such as diltiazem, SQ 31,765 or SQ 32,324 and a thromoboxane A.sub.2 receptor antagonist such as SQ 30,741 or a thromboxane synthetase inhibitor such as dazoxiben.

REFERENCES:
patent: 4663336 (1987-05-01), Nakane et al.
L. Szekeres et al, Br. J. Pharmacol. 86:341-350, 1985.
G. Grover et al, Eur. J. Pharmacol. 143:109-117, 197.
R. Conway et al, J. Clin. Invest. 70:320-329, 1982.
G. Grover et al, J. Cardiovasc. Pharmacol. 11:29-35, 1988.

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