Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1995-06-06
2000-02-29
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241541, 4241561, 4241581, 4241721, 424 852, 5303871, 5303881, 53038823, 53038824, 53038875, 5303892, 530351, A61K 39395, A61K 3819, C07K 1452, C07K 1600
Patent
active
060306157
ABSTRACT:
There is disclosed a method for treating an individual having a disease caused by cytokine-mediated toxicity comprising administering to the individual an effective amount of (a) an antibody that binds to an MIF polypeptide, wherein the MIF polypeptide has a molecular weight of about 12.5 kDa in combination with (b) anti-TNF.alpha., anti-IL1, anti-IFN-.gamma., IL-1RA, a steroid, a glucocorticoid, or IL-10.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4708937 (1987-11-01), Remold
patent: 5411882 (1995-05-01), Odink et al.
Natanson et al. Ann. Int. Med. 120(9)771-783, 1994.
Zuckerman et al. Eur.J.Immunol. 19:301-305, 1989.
The Physician's Desk Reference, 1990. ed. Publ. by Edward R. Barnhart; pp. 1341-1342.
David et al., "Delayed Hypersensitivity in Vitro: Its Mediation By Cell Free Substances Formed By Lymphold Cell-Antigen Interaction", Pathology 56:72-77 (1966).
Bennett and Bloom, "Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity", Science 153:80-82 (1966).
Nathan et al., "Alterations of Macrophage by Mediators From Lymphocytes", J Exp Medicine 133:1356-1376 (1971).
Nathan et al., "Characterization of a Lymphocyte Factor Which Alters Macrophage Functions", J Exp Medicine 137:275-288 (1973).
Kohler and Milstein, "Continuous Culture of Fused Cells Secreting Antibody of Predefined Specifity" Nature 256:495-497 (1975).
Weiser et al., "Studies of Human Migration Inhibitory Factor: Characterization of Three Molecular Species", J Immunol 126:1958-1962 (1981).
Kaiser and Kezdy, "Secondary Structures of Proteins and Peptides in Amphiphilic Environments (A Review )", Proc Natl Acad Sci USA 80:1137-1143 (1983).
Peck, "The ELISA Method for Quantitation of Macrophage Migration from Agarose Microdroplers", Immunol Methods 64:179-187 (1983).
Morrison et al., "Chimeric Human Antibody Molecules: Mouse Antigen-Binding Domains with Human Constant Region Domains", Proc Natl Acad Sci 81:6851-6855 (1984).
Sprung et al., "The Effects of High Dose Corticosteroids in Patients with Septic Shock", New Eng Eng J Med 311:1137-1143 (1984).
Beutler et al., "Purification of Catechin, A Lipoprotein Lipase-Suppressing Hormone Secreted by Endotoxin-Induced Raw 264.7 Cells", J Exp Med 161:984-995 (1985).
Erne et al., "Preferred Confirmation, Orientation, and Accumulation of Dynorphin A-(1-13)-Tridecapeptides on the Surfaces of Neutral Lipid Membranes", Biochemistry 24:4263-4265 (1985).
Beutler et al., "Catechin/Tumor Necrosis Factor: Production, Distribution, and Metabolic Fate in Vivo", J Immunol 135:3972-3977 (1985).
Suzuki et al., "Pituitary-Dependent and Independent Secretion of CS Caused by Bacterial Endotoxin in Rats", Am J Physiol 250:E470-E474 (1986).
Liu and Todd, "A Monoclonal Antibody Specific for a Monocyte-Macrophage Membrane Component Blocks the Human Monocyte Response to Migration Inhibitory Factor", J Immuno 137:448-455 (1986).
Thomas and Cappechi, "Site-Directed Mutagen by Gene Targeting in Mouse Embryo-Derived Stem Cells", Cell 51:503-512 (1987).
Bone et al., "A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock", New Eng J Med 311:1137-1141 (1987).
Ding et al., "Release of Reactive Nitrogen Intermediates and Reactive Oxygen Intermediates From Mouse Peritoneal Macrophages", J Immunol 141:2407-2413.
Smith, "Interleukin 2: Inception, Impact, and Implications", Science 240:1169-1176 (1988).
Michie et al., "Detection of Circulating Tumor Factor After Endotoxin Administration", New Eng J Med 318:1481-1486 (1988).
Wolpe et al., "Macrophages Secrete a Novel Heparin--Binding Protein With Imflammatory and Neutrophil Chemokinetic Properties", J Exp Medicine 167:570-581 (1988).
Huse et al., "Generation of a Large Combinatorial Library of the Immunoglobin Repertoire in Phage Lambda", Science 246:1275-1281 (1989).
Sternberg et al., "Inflammatory Mediator-Induced Hypothalamic-Pituitary-Adrenal Axis Activation is Defective in Streptococcal Cell Wall Arthritis-Susceptible Lewis Rats", Proc Natl Acad Sci USA 86:2374-2378 (1989).
Weiser et al., "Molecular Cloning of cDNA Encoding Human Macrophage Migration Inhibitory Factor ", Proc Natl Acad Sci 86:7522-7526 (1989).
Zuckerman et al., "Differential Regulation of Lipopolysaccharide-Induced Interleukin 1 and Tumor Necrosis Factor Synthesis: Effects of Endogenous and Exogenous Glucocorticoids and the Role of the Pituitary-Adrenal Axis", Eur J Immunol 19:301-305 (1989).
Uhlmann and Peyman, "Antisense Oligonucleotides: A New Therapeutic Principle", Chem Rev 90:543-584 (1990).
Buhler et al., "Rabbit .beta.-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits", Biotechnology 8:140-143 (1990).
Edwards III et al., "Hypophysectomy Inhibits the Synthesis of Tumor Necrosis Factor .alpha.by Rat Macrophages: Partial Restoration by Exogenous Growth Hormone or Interferon .gamma.", Endocrinol 128:989-986 (1991).
Dinarello, "The Proinflammatory Cytokines Interleukin-1 and Tumor Necrosis Factor and Treatment of the Septic Shock Symdrome", J Infect Dis 163:1177-1184 (1991).
Edwards III et al., "The Pituitary is Required for Protection Against Lethal Effects of Salmonella Typhimurium", Proc Natl Acad Sci USA 88:2274-2277 (1991).
Silverstein et al., "Hydrazine Sulfate Protects D-Galactosamine-Sensitized Mice Against Endotoxin and Tumor Necrosis Factor.backslash.Cachetin Lethality: Evidence of a Role for the Pituitary", J Exp Med 173:357-365 (1991).
Lam et al., "A New Type of Synthetic Peptide Library for Identifying Ligand Binding Activity", Nature 354:82-84 (1991).
Fung-Leung et al., "CD8 is Needed for the Development of Cytotoxic T-Cells but not Helper T-Cells", Cell 65:443-449 (1991).
Holmes et al., "Structure and Functional Expression of a Human Interleukin-8 Receptor", Science 253:1278-1280 (1991).
Weiser et al., "Human Recombinant Migration Inhibitory Factor Activates Human Macrophages to Kill Leishmania Donovani", J Immunol 147:2006-2011 (1991).
Pozzi et al., "Human Recombianant Migration Inhibitory Factor Activates Human Macrophages to Kill Tumor Cells", Cellular Immunol 145:372-379 (1992).
Fry et al., "Solution Structures of Cyclic and Dicylic Anologues of Growth Hormone Releasing Factor as Determined by Two-Dimensional NMR and CD Spectroscopies and Constrained Molecular Dynamics", Biopolymer 32:649-666 (1992).
Sigal and Dumont, "Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction", Ann Rev Immunol 10:519-560 (1992).
Blocki et al., "Rat Liver Protein Linking Chemical and Immunological Detoxification Systems", Nature 360:269-270 (1992).
Vassalli, "The Pathophysiology of Tumor Necrosis Factors", Ann Rev Immunol 10:411-452 (1992).
Weiser et al., "Recombinant Human Migration Inhibitory Factor has Adjuvant Activity", Procl Natl Acad Sci USA 89:8049-8052 (1992).
Lanahan et al., "Growth Factor-Induced Delayed Early Resonse Genes", Mol Cell Biol 12:3919-3929 (1992).
Sherry et al., "Identification of Cyclophilin as a Proinflammatory Secretory Product of Lipopolycaccharide-Activated Macrophages", Proc Natl Acad Sci USA 89:3511-3515 (1992).
Bernhagen et al., "Indentification of Macrophage Migration Inhibitory Factor (MIF) as an LPS-Induced Pituitary Protein in Vitro and in Vivo", J Cell Biochem. Supplement 17B, Abstract E306 (1993).
Wistow et al., "A Macrophage Migration Inhibitory Factor is Expressed in the Differentiating Cells of the Eye Lens", Proc Natl Acad Sci USA 90:1272-1275 (1993).
Bernhagen et al., "MIF is a Pituitary-Derived Cytokine that Potentiates Lethal Endotoxaemia", Nature 365:756-759 (1993).
Mikayama et al., "Molecular Cloning and Functional Expression of a cDNA Encoding Glycosylation-Inhibiting Factor", Proc Natl Acad Sci USA 89:10056-10060 (1993).
Cunha et al., "Recombinant Migration Inhibitory Factor Induces Nitric Oxide Synthase in Murine Macrophages", J Immunol 150:1908-1912 (1993).
Bernhagen Jurgen
Bucala Richard J.
Calandra Thierry F.
Cerami Anthony
Mitchell Robert A.
Bansal Geetha P.
Hutzell Paula K.
The Picower Institute for Medical Research
Tremaine Davis Wright
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