Combination kit used in the treatment of malaria

Details Combination kit used in the treatment of malaria Combination kit used in the treatment of malaria

2008-07-29

2008-07-29

Henley, III, Raymond J. (Department: 1614)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

C424S272100, C546S171000

Reexamination Certificate

active

07404962

ABSTRACT:
A combination kit for the treatment of malaria caused byPlasmodium vivax(P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

REFERENCES:
patent: 4431807 (1984-02-01), Strube et al.
patent: 5373005 (1994-12-01), McCann et al.
J.S. Lunn et al., “Antibody production in Plasmodium vivax infections suppressed by weekly doses of chloroquine”, American Journal of Tropical Medicine and Hygiene, (Sep. 1965), 14(5), pp. 697-699.
K. Kar et al., “Pharmacology of Compound CDRI 80/53; A Potential New Anti-Relapde Antimalarial Agent”, Indian Journal of Parasitology, (1988), pp. 259-262.
Paliwal, Jyoti Kumar and Ram Chandra Gupta. “A Rapid and Sensitive High Performance Liquid Chromatographic Assay of the New Antimalarial Compound 80/53 in Serum with a Novel Sample Clean-up Method and its Pharmacokinetics in Rabbits. Journal of Pharmaceutical and Biomedical Analysis.” vol. 17, pp. 775-783 (1998).

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