Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-16
1994-11-15
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514373, A61K 31445, A61K 31425, A61K 31645, A61K 31505
Patent
active
053648579
ABSTRACT:
The effect of neuroprotective 5-HT.sub.2 -receptorantagonistic 4-fluoro-phenyl compounds is intensified synergistically by 5-HT.sub.1A -receptoragonistic aminomethyl-chromans. The combination of 5-HT.sub.1A -receptoragonistic aminomethyl-chromans and 5-HT.sub.2 -receptorantagonistic 4-fluoro-phenyl compounds is suitable for the treatment of cerebral ischaemias.
REFERENCES:
patent: 3041344 (1962-06-01), Janssen
patent: 3155669 (1964-11-01), Janssen
patent: 3155670 (1964-11-01), Janssen
patent: 3161644 (1964-12-01), Janssen
patent: 3919425 (1975-11-01), Vidrio
patent: 4335127 (1982-06-01), Vandenberk et al.
patent: 4342870 (1982-08-01), Kennis et al.
patent: 4522945 (1985-06-01), Vandenberk et al.
patent: 4859665 (1989-08-01), Garthoff et al.
patent: 4988700 (1991-01-01), Traber et al.
patent: 5070102 (1991-12-01), Traber et al.
patent: 5137901 (1992-08-01), Junge et al.
patent: 5155128 (1992-10-01), Traber et al.
patent: 5200410 (1993-04-01), Traber et al.
Brogden et al., Medline (NLM), 91176900, 1990.
Anonymous, Medline (NLM), 89194457, 1989.
Doyle, Medline (NLM), 91137288, 1990.
Journal of Cerebral Blood Flow and Metabolism 1, 155-185 (1981).
J. Pharmacol. Exp. Ther. 238, 248-253 (1986).
Molecular Pharmacology 16, 687-699 (1979).
J. Neurochem. 36, 220-226 (1981).
J. Pharmacol. Exp. Ther. 244, 1051-1065 (1988).
STN International, Karlsruhe; File "CA", Chemical Abstracts, vol. 115(17):180699; Blockade of 5-HT2 Receptors Protects Against Impairment . . ., 1991.
STN International, Karlsruhe; File "PHAR", Pharmaprojects; Copyright 1993; 2,4(1H,3H)-Quinazolinedione . . ., No. 006750.
Brain Research, 578 (1992), 1-7; "Ketanserin Reduces Neuronal Calcium Accumulation and Cell Death in the Hippocampus of the Mongolian Gerbil . . .".
Cintins Marianne M.
Jarvis William R. A.
Troponwerke GmbH & Co KG
LandOfFree
Combination having a neuroprotective effect does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Combination having a neuroprotective effect, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Combination having a neuroprotective effect will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1097928