Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2007-01-23
2007-01-23
Romeo, David S (Department: 1647)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C514S012200, C514S002600, C514S008100, C530S350000, C530S300000
Reexamination Certificate
active
10991592
ABSTRACT:
Acute and chronic heart disease is treated using a rational, multi-tier approach. A patient is pretreated with growth factor proteins or gene therapy, followed by the administration of adult stem cells. The progress of treatment is continuously monitored by echo-cardiogram with growth factor treatment and/or stem cell administration adjusted according to the results of the echo-cardiogram or clinical status of the patient. Heart disease is also treated by a method that comprises administration of a therapeutically effective amount of a growth factor protein by oral inhalation therapy.
REFERENCES:
patent: 4296100 (1981-10-01), Franco
patent: 5858968 (1999-01-01), Weiner et al.
patent: 5915378 (1999-06-01), Lloyd et al.
patent: 5952008 (1999-09-01), Backstrom
patent: 5980887 (1999-11-01), Isner et al.
patent: 6099832 (2000-08-01), Mickle et al.
patent: 6387369 (2002-05-01), Pittenger et al.
patent: 6599741 (2003-07-01), Hecker et al.
patent: 6607720 (2003-08-01), Xiao et al.
patent: 6620784 (2003-09-01), Ferrara et al.
patent: 6673604 (2004-01-01), Edge
patent: 2002/0051762 (2002-05-01), Rafii et al.
patent: 2002/0061587 (2002-05-01), Anversa
patent: 2002/0098167 (2002-07-01), Anversa
patent: 2002/0172663 (2002-11-01), Palasis
patent: 2003/0008351 (2003-01-01), Deisher et al.
patent: 2003/0054973 (2003-03-01), Anversa
patent: 2003/0082153 (2003-05-01), Epstein et al.
patent: 2003/0148968 (2003-08-01), Hammond et al.
patent: 2003/0199464 (2003-10-01), Itescu
patent: 2003/0232431 (2003-12-01), Law
patent: 2004/0018174 (2004-01-01), Palasis
patent: 2004/0076619 (2004-04-01), Anversa et al.
patent: 2004/0087016 (2004-05-01), Keating et al.
patent: 2004/0126879 (2004-07-01), Schneider et al.
Retuerto et al., Journal of Thoracic and Cardiovascular Surgery, vol. 127, Issue 4, Apr. 2004, pp. 1041-1050.
Kawamoto et al. Circulation. 2004;110:1398-1405.
Patton, John S. “Mechanisms of Macromolecule Absorption by the Lungs”,Advanced Drug Delivery Systems1996;19: 3-36.
Hughes, S. “Cardiac Stem Cells”,J. of PathologyJul. 2002; 194 (4): 468-78.
Dengler, TJ et al. Stem Cell Therapy for the Infarcted Heart (‘Cellular Cardiomyoplasty’),HerzNov. 2002; 27 (7): 598-610.
Chiu, RC “Adult Stem Cell Thereapy for Heart Failure”,Expert Opinion Biol. Ther.Apr. 2003; 3 (2): 215-25.
Nir, SG et al. “Human Embryonic Stem Cells for Cardiovascular Repair”,Cardiovascular Res.May 1, 2003; 58 (2):313-23.
Itescu, S.“New Directions in Strategies Using Cell Therapy for Heart Disease”,J. of Molecular Med.May 2003; 81(5): 288-96. Epub Apr. 16, 2003.
Sim, EK et al. “Skeletal Myoblast Transplant in Heart Failure”,J. of Card. Surg.Jul.-Aug. 2003; 18 (4): 19-27.
Goette, A et al.“Effect of Atrial Fibrillation on Hematopoietic Progenitor Cells: A Novel Pathophysiological Role of Atrial Natriuretic Peptide?”,CirculationNov. 18, 2003; 108 (20): 2446-9. Epub Nov. 10, 2003.
Strauer, BE et al. “Stem Cell Therapy in Acute Myocardial Infarction” (in German),Med. Klin.Dec. 15, 2003; 98 Suppl 2:14-8.
Aschermann, M et al. “Use of Stem Cells for Myocardial Regeneration” (in Czech),Cas. Lek Cesk.2004; 143 (2): 71-4.
Ng, YS et al. “Identification of Genes Involved in VEGF-Mediated Vascular Morphogenesis Using Embryonic Stem Cell-Derived Cystic Embryoid”,Lab. Invest.Jun. 28, 2004.
Kawai,T et al. “Efficient Cardiomyocenic Differentiation of Embryonic Stem Cell by Fibroblast Growth Factor 2 and Bone Morphogenetic Protein 2”,Circ. J.Jul. 2004; 68 (7): 691-702.
Xu, W et al. “Mesenchymal Stem Cells From Adult Human Bone Marrow Differentiate Into a Cardiomyocyte Phenotypein vitro”, Exp. Biol. Med(Maywood) Jul. 2004; 229 (7): 623-31.
Lee MS et al. “Stem Cell Transplantation in Myocardial Infarction”,Reviews in Cardiovascular Medicine2004; 5 (2): 82-98.
Lin, G-S et al. “Autologous Transplantation of Bone Marrow Mononuclear Cells Improved Heart Function After Myocardial Infarction”,Acta Pharmacologica SinicaJul. 2004; 25 (7):876-886.
Buff Ernest D.
Ernest D. Buff & Associates LLC
Gamett Daniel C
Pierson Theodore J.
Romeo David S
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