Combination chemotherapy compositions and methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C424S649000, C514S274000, C514S449000, C514S492000

Reexamination Certificate

active

07906554

ABSTRACT:
This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.

REFERENCES:
patent: 6380405 (2002-04-01), Ekwuribe et al.
patent: 2337256 (2000-01-01), None
patent: 1312712 (2001-09-01), None
patent: 267155 (1988-05-01), None
patent: 5-070348 (1993-03-01), None
patent: WO 80/02098 (1980-10-01), None
patent: 98/08503 (1998-03-01), None
patent: WO98/08503 (1998-03-01), None
patent: WO 98/17662 (1998-04-01), None
patent: WO 99/49862 (1999-10-01), None
patent: 00/03707 (2000-01-01), None
patent: WO 00/66576 (2000-11-01), None
patent: 01/17986 (2001-03-01), None
patent: WO 02/02548 (2002-01-01), None
patent: 03/086386 (2003-10-01), None
Khoshyomn, et al, Synergistic Action of Genistein and Cisplatin on Growth Inhibition and Cytotoxicity of Human Medulloblastoma Cells,Pediatric Neurosurgery; Sep. 2000; 33, 3; p. 123-131.
Suggitt and Bibby, Clinical Cancer Research, 2005, vol. 11, 971-981.
STN File Medline, abstract accession No. 2003459262 & Tamura S. et al., Pigment Cell Research, (Oct. 2003) 16 (5) 470-6, “Genistein enhances the ciplatin-induced inhibitions of cell growth and apoptosis in human malignant melanoma cells”.
STN File Biosis, abstract accession No. 2003:368481 & Mansour A. et al., Blood (Nov. 16, 2002) vol. 100, No. 11, pp. Abstract No. 4997, “Enhancement of chemotherapeutic efficacy by combining agents that block IL-10 in CIL cell lines”.
STN File Medline, abstract accession No. 2002151803 & S. Giacomelli et al., Life Sciences (Feb. 8, 2002), pp. 1447-1459, “Silybin and its bioavailable phospholipids complex (IdB 1016) potentiate in vitro and in vivo in the activity of cisplatin”.
STN File Medline, abstract accession No. 2000404390 & Caltagirone S. et al, International Journal of Cancer (Aug. 15, 2000), 87 (4), pp. 595-600, “Flavanoids apigenin and quercetin inhibit melanoma growth and metastatic potential”.
STN File Medline, abstract accession No. 96273517 & Scambia G. et al, European Journal of Cancer (May 1996), 32A(5), pp. 877-882, “Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin”.
STN File Medline, abstract accession No. 91191699 & Waud W. R. et al, Cancer Chemotherapy and Pharmacology (1991), 27(6), pp. 456-463, “Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia”.
STN File Medline, abstract accession No. 91107211 & Neelam S. S. et al, Investigational New Drugs (Aug. 1990), 8 (3), pp. 263-268, “Combination of flavone acetic acid (FAA) with adriamycin, cisplatinum and difluoromethylornithine (DFMO) in vitro against human colon cancer cells”.
STN File Medline, abstract accession No. 92032982 & Scambia G. et al, Anti-Cancer Drugs (Oct. 1990), 1 (1), pp. 45-48, “Synergistic antiproliferative activity of quercetin and cisplatin on ovarian cancer cell growth”.
STN File CA, abstract No. 119:131038 & De Vincenzo R. et al, Acta Medica Romana (1992), 30 (1-2), pp. 126-132, “Flavanoids and negative control of cell proliferation in ovarian tumors”.
Zyner E. et al, Acta Poloniae Pharmaceutica Drug Research, 1999, 56(2), pp. 159-167, “Platinum (II) and palladium (II) N, O-chelates with substituted flavanone containing ligands”.
Zyner E. et al, Pharmazie, 1999, 54 (12), pp. 945-946, “Pt (II) and Pd (II) complexes of 3-aminoflavone: in vitro and in vivo evaluation”.
Lei W. et al, Anticancer Research, 1999, vol. 19, pp. 221-228, “Enhancement of chemosensitivity and programmed cell death by tyrosine kinase inhibitors correlates with EGFR expression in non-small cell lung cancer cells”.
Kang B-J et al, Natural Product Sciences, 2000, 6(4), pp. 165-169, “Scientific analysis of formulation theory of Chungpesagan-tang; in vitro cytotoxicity of cisplatin combined with Chungpesagan-tang”.
Sepulveda-Boza, S et al, “The Preparation of New Isoflavones”, Synthetic Communications (2001) vol. 31 No. 12 pp. 1933-1940.
O'Neil, M J. et al, “Inducible Isoflavonoids from the Lima Bean, Phaseolus lunatus”, Phytochemistry (1986) vol. 25, No. 6 pp. 1315-1322.
Wolfbeis, O S et al, “The Absorption and Fluorescence of Isoflavones and the Effect of Shift Regents”, Z. Naturforsch (1984) 39b pp. 238-243.
Arora, S K et al, “The Synthesis of Tlatlancuayin”, Tetrahedron (1962) vol. 18 pp. 559-565.
STN Chemical Abstract Accession No. 135: 355315 & Chemical and Pharmaceutical Bulletin (2001), 49 (9), 1229-1231.
STN Chemical Abstract Accession No. 135:121648 & Journal of Agricultural and Food Chemistry (2001), 49 (6) 3024-3033.
STN Chemical Abstract Accession No. 124:341448 & Archives of Microbiology (1995), 164 (6), 428-34.
STN Chemical Abstract Accession No. 124:316797 & Chemical and Pharmaceutical Bulletin (1996), 44 (3), 486-91.
STN Chemical Abstract Accession No. 124: 140985 & Tennen Yuki Kagobutsu Toronkai Koen Yoshishu (1995), 37th, 493-8.
STN Chemical Abstract Accession No. 115:68424 & Phytochemistry (1991), 30 (4), 1281-4.
STN Chemical Abstract Accession No. 114:41246 & Angewandte Botanik (1990), 64 (1-2), 175-90.
STN Chemical Abstract Accession No. 112:69573 & International Journal of Tissue Reactions (1989), 11 (3), 107-12.
STN Chemical Abstract Accession No. 102:59329 & Phytochemistry (Elsevier) (1984), 23 (11), 2703-4.
STN Chemical Abstract Accession No. 102:59220 & Phytochemistry (Elsevier) (1984), 23 (6), 1342-3).
STN Chemical Abstract Accession No. 97:109739 & J. Chem. Soc., Perkin Trans. 1 (1982), (6), 1389-94.
STN Chemical Abstract Accession No. 95:111690 & Phytochemistry (1981), 20 (4), 799-801.
STN Chemical Abstract Accession No. 82:97918 & J. Inst. Chem., Calcutta (1974), 46, Pt. 3, 61-5.
STN Chemical Abstract Accession No. 76:140428 & J. Inst. Chem., Calcutta (1971), 43 (6), 234-40.
STN Chemical Abstrac Accession No. 70:57577 Indian J. Chem. (1968), 6 (9), 481-4.
STN Chemical Abstract Accession No. 63:54547 & Bull. Chem. Soc. Japan (1965), 38 (6), 887-93.
STN Chemical Abstract Accession No. 61:61569 & Periodica Polytech. (1963), 7 (4), 241-58.
STN Chemical Abstract Accession No. 126:139728 (see CAS RN 116718-84-4) & Atherosclerosis (1997), 128 (1), 59-66.
Jha, H C et al, “Carbon-13 Chemical Shift Assignments of Chromones and Isoflavones”, Can. J. Chem. (1980) vol. 58 No. 12 pp. 1211-1219.
STN Chemical Abstracts Accession No. 128:164027 & Antioxidants in Health and Disease (1998), 7 (Flavanoids in Health and Disease) pp. 295-302.
STN Chemical Abstracts Accession No. 117:124019 & Biochemical Pharmacology (1992) vol. 44 (1), pp. 157-162.
Abstract XP002541865, “Phenoxodiol enters phase II leukemia trial”, DailyDrugNews.com (Daily Essentials), Sep. 26, 2002.
Andreas I. Constantinou, et al., “Phenoxodiol (2H-1-Benzopyran-7-0,1,3-(4-hydroxyphenyl)), A Novel Isoflavone Derivative, Inhibits DNA Topoisomerase II by Stabilizing the Cleavable Complex”, Anticancer Research, vol. 22, No. 5, pp. 2581-2586, Sep. 2002.
Tito Fojo, et al., “Taxol and other microtubule-interactive agents”, Current Opinion in Oncologic, Endocrine and Metabolic Investigational Drugs, vol. 2, No. 3, pp. 293-304, Jan. 1, 2000.
Dirk Th. Sleijfer, et al., “Cisplatin: a review of clinical applications and renal toxicity”, Pharmaceutish Weekblad Scientific Edition, vol. 7, No. 6, pp. 237-244, Dec. 13, 1985.
Antona J. Wagstaff, et al., “Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer”, Drugs, vol. 37

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